DegronMD

Uniprot ID: Q9Y5G2

Source protein: Protocadherin gamma-B2

Source gene: PCDHGB2

Class: DEG_SCF_FBW7_2

Location: 352:358

E3 ligase: FBXW7

DEGRON score: 0.9198

ASA_SCORE: 66.7143

COIL: 0.9007

CONS_SCORE: 0.5452

DSS_SCORE: 0.5176

HELIX: 0.0206

FCONS_SCORE: 0.9538

RIG_SCORE: 0.6995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L356I	TCGA-17-Z031	LUAD	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.6063
p.G363E	TCGA-22-5480	LUSC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.1944
p.G363E	DO26786	LUSC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.1944
p.D342A	TCGA-27-1837	GBM	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.0556
p.D342A	DO12010	GBM	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.0556
p.S360L	TCGA-B5-A3FA	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.2778
p.S360L	DO52402	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.2778
p.D342N	TCGA-B5-A3S1	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.0556
p.D342N	DO41277	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.0556
p.E358D	TCGA-BS-A0UF	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.6758
p.E358D	DO41488	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.6758
p.S353P	TCGA-BS-A0UV	UCEC	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.5641
p.S353P	DO42793	UCEC	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.5641
p.P355S	TCGA-FW-A3R5	SKCM	TCGA	VSTPLPE	DEG_SCF_FBW7_2	0.6752
p.P355S	DO37406	SKCM	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.6752
p.D342E	DO230329	COCA	ICGC	VSTPLPE	DEG_SCF_FBW7_2	0.0556
p.S351L	SIDM01174	Cervical Carcinoma	GDSC	VSTPLPE	DEG_SCF_FBW7_2	0.3056
p.S351L	ACH-001402	Cervical Cancer	CCLE	VSTPLPE	DEG_SCF_FBW7_2	0.3056
p.S351L	SW756	cervix	COSMIC	VSTPLPE	DEG_SCF_FBW7_2	0.3056
p.A344V	SIDM00683	Prostate Carcinoma	GDSC	VSTPLPE	DEG_SCF_FBW7_2	0.1111
p.A344V	ACH-000977	lymph_node	CCLE	VSTPLPE	DEG_SCF_FBW7_2	0.1111
p.A344V	LNCaP-Clone-FGC	prostate	COSMIC	VSTPLPE	DEG_SCF_FBW7_2	0.1111
p.P362Q	ACH-002800	Unknown	CCLE	VSTPLPE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5G2	Protocadherin gamma-B2	DEG_SCF_FBW7_2	352:358	VSTPLPE	FBXW7	0.9198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons