DegronMD - Q9H078(CLPB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K702N	TCGA-BR-8591	STAD	TCGA	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation rewiring degron network	0.3056
p.R417Q	TCGA-BS-A0UM	UCEC	TCGA	PPGY	ITCH	427:430	Mutation rewiring degron network	0.0556
p.Y279C	TCGA-BT-A3PK	BLCA	TCGA	DYR	CBL_MET	278:280	Mutation altering degron motif	0.7087
p.A696V	TCGA-CV-5441	HNSC	TCGA	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation altering degron motif	0.5825
p.P700A	TCGA-D3-A3MV	SKCM	TCGA	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation altering degron motif	0.6392
p.V274I	TCGA-KU-A66S	HNSC	TCGA	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.2222
p.R282C	DO233871	GACA	ICGC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.2778
p.R282C	DO51761	STAD	ICGC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.2778
p.R287S	DO228974	LICA	ICGC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.1389
p.S271R	DO220011	SARC	ICGC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.1389
p.T706A	SIDM00773	Non-Cancerous	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation rewiring degron network	0.1944
p.T706A	SIDM00774	Breast Carcinoma	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation rewiring degron network	0.1944
p.E284V	SIDM01133	Other Solid Cancers	GDSC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.2222
p.E284V	NCI-H835	lung	COSMIC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.2222
p.R280G	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	278:280	Mutation altering degron motif	0.7568
p.R280G	NCI-H1573	lung	COSMIC	DYR	CBL_MET	278:280	Mutation altering degron motif	0.7568
p.R695W	SIDM00785	Acute Myeloid Leukemia	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation altering degron motif	0.8634
p.R695W	SIDM00628	Breast Carcinoma	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation altering degron motif	0.8634
p.R695W	SIDM01752	Pancreatic Carcinoma	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	695:701	Mutation altering degron motif	0.8634
p.E419K	SIDM01609	Endometrial Carcinoma	GDSC	PPGY	ITCH	427:430	Mutation rewiring degron network	0.1111
p.E435V	ACH-000216	Esophageal Cancer	CCLE	PPGY	ITCH	427:430	Mutation rewiring degron network	0.1944
p.G269V	ACH-001450	Lymphoma	CCLE	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.0833
p.R284C	LoVo	large intestine	COSMIC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.2222
p.R270C	LoVo	large intestine	COSMIC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.1111
p.E288Q	NCI-H211	lung	COSMIC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.1111
p.E274Q	NCI-H211	lung	COSMIC	DYR	CBL_MET	278:280	Mutation rewiring degron network	0.2222

Kaplan plot for CLPB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLPB

UniProt ID: Q9H078

Entrez ID: 81570

Protein name: Caseinolytic peptidase B protein homolog (EC 3.6.1.-) (Suppressor of potassium transport defect 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLPB in