DegronMD

Uniprot ID: Q9H078

Source protein: Caseinolytic peptidase B protein homolog

Source gene: CLPB

Class: LIG_APCC_ABBAyCdc20_2

Location: 695:701

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.647

ASA_SCORE: 90.3143

COIL: 0.8206

CONS_SCORE: 0.1553

DSS_SCORE: 0.46

HELIX: 0.1516

FCONS_SCORE: 0.9386

RIG_SCORE: 0.7421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K702N	TCGA-BR-8591	STAD	TCGA	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A696V	TCGA-CV-5441	HNSC	TCGA	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.5825
p.P700A	TCGA-D3-A3MV	SKCM	TCGA	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.6392
p.T706A	SIDM00773	Non-Cancerous	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.T706A	SIDM00774	Breast Carcinoma	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R695W	SIDM00785	Acute Myeloid Leukemia	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R695W	SIDM00628	Breast Carcinoma	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R695W	SIDM01752	Pancreatic Carcinoma	GDSC	RAPLHPE	LIG_APCC_ABBAyCdc20_2	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H078	Caseinolytic peptidase B protein homolog	LIG_APCC_ABBAyCdc20_2	695:701	RAPLHPE	APC,CDC20,FZR1	0.647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons