DegronMD - Q15003(NCAPH)

FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA int... View more >>

GO - Biological processes (BP): cell division [GO:0051301]; female meiosis chromosome separation [GO:0051309]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076]; positive regulation of chromosome condensation [GO:1905821]; positive regulation of chromosome segregation [GO:0051984]; positive... View more >>

GO - Molecular function (MF): chromatin binding [GO:0003682]

GO - Cellular component (CC): condensed nuclear chromosome [GO:0000794]; condensin complex [GO:0000796]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DYR	CBL_MET	CBL	Condensin complex subunit 2	269:271	More..
IPGTPVLE	DEG_SCF_FBW7_2	FBXW7	Condensin complex subunit 2	46:53	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R53L	DO229048	LICA	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.8428
p.R271I	TCGA-AX-A2HC	UCEC	TCGA	DYR	CBL_MET	269:271	Mutation altering degron motif	0.8102
p.Q46H	DO229025	LICA	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7582
p.Q270H	ACH-000893	Lung Cancer	CCLE	DYR	CBL_MET	269:271	Mutation altering degron motif	0.7582
p.Q270H	NCI-H1651	lung	COSMIC	DYR	CBL_MET	269:271	Mutation altering degron motif	0.7582
p.P52L	COLO-824	breast	COSMIC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7582
p.T271S	DO218987	BLCA	ICGC	DYR	CBL_MET	269:271	Mutation altering degron motif	0.7116
p.E53K	TCGA-CN-6016	HNSC	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7022
p.E53K	SIDM01611	Endometrial Carcinoma	GDSC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.7022
p.D49N	DO231566	LINC	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.6932
p.P50S	TCGA-D3-A2JL	SKCM	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation altering degron motif	0.6752
p.K41Q	TCGA-VQ-A8P2	STAD	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation blocking ubiquitination signal	0.6389
p.D54A	TCGA-AA-A00N	COAD	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.3056
p.Q55E	ACH-001494	Bile Duct Cancer	CCLE	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.2778
p.T274M	DO48579	BLCA	ICGC	DYR	CBL_MET	269:271	Mutation rewiring degron network	0.25
p.D43A	DO9876	COAD	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.25
p.R56Q	DO50265	PAAD	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.25
p.P266S	ACH-002309	Sarcoma	CCLE	DYR	CBL_MET	269:271	Mutation rewiring degron network	0.25
p.P266S	SW684	soft tissue	COSMIC	DYR	CBL_MET	269:271	Mutation rewiring degron network	0.25
p.E42K	DO14470	HNSC	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	46:53	Mutation rewiring degron network	0.2222

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCAPH

UniProt ID: Q15003

Entrez ID: 23397

Protein name: Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCAPH in