DegronMD

Uniprot ID: Q15003

Source protein: Condensin complex subunit 2

Source gene: NCAPH

Class: DEG_SCF_FBW7_2

Location: 46:53

E3 ligase: FBXW7

DEGRON score: 0.9671

ASA_SCORE: 87.325

COIL: 0.9028

CONS_SCORE: 0.2704

DSS_SCORE: 0.6342

HELIX: 0.0513

FCONS_SCORE: 0.7355

RIG_SCORE: 0.6737

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R53L	DO229048	LICA	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.8428
p.Q46H	DO229025	LICA	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.7582
p.P52L	COLO-824	breast	COSMIC	IPGTPVLE	DEG_SCF_FBW7_2	0.7582
p.E53K	TCGA-CN-6016	HNSC	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	0.7022
p.E53K	SIDM01611	Endometrial Carcinoma	GDSC	IPGTPVLE	DEG_SCF_FBW7_2	0.7022
p.D49N	DO231566	LINC	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.6932
p.P50S	TCGA-D3-A2JL	SKCM	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	0.6752
p.K41Q	TCGA-VQ-A8P2	STAD	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	0.6389
p.D54A	TCGA-AA-A00N	COAD	TCGA	IPGTPVLE	DEG_SCF_FBW7_2	0.3056
p.Q55E	ACH-001494	Bile Duct Cancer	CCLE	IPGTPVLE	DEG_SCF_FBW7_2	0.2778
p.D43A	DO9876	COAD	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.25
p.R56Q	DO50265	PAAD	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.25
p.E42K	DO14470	HNSC	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.2222
p.E42K	ACH-000996	Endometrial/Uterine Cancer	CCLE	IPGTPVLE	DEG_SCF_FBW7_2	0.2222
p.R58H	DO227709	COCA	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.1944
p.P39S	DO47278	SKCM	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.1389
p.H60Q	OVK-18	ovary	COSMIC	IPGTPVLE	DEG_SCF_FBW7_2	0.1389
p.D63Y	DO41133	UCEC	ICGC	IPGTPVLE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15003	Condensin complex subunit 2	DEG_SCF_FBW7_2	46:53	IPGTPVLE	FBXW7	0.9671	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons