DegronMD - Q8N7X1(RBMXL3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R261H	TCGA-AA-3947	COAD	TCGA	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0556
p.R261H	TCGA-AP-A1DV	UCEC	TCGA	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0556
p.R261H	DO8192	COAD	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0556
p.R261H	DO43186	UCEC	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0556
p.R262H	TCGA-B5-A11N	UCEC	TCGA	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0833
p.R262H	DO41458	UCEC	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0833
p.G277C	TCGA-B5-A1MX	UCEC	TCGA	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.2222
p.G277C	DO41999	UCEC	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.2222
p.R210Q	TCGA-CM-6678	COAD	TCGA	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.7329
p.R210Q	DO10220	COAD	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.7329
p.R210Q	SIDM01182	Bladder Carcinoma	GDSC	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.7329
p.E290Q	TCGA-EK-A2PG	CESC	TCGA	DHEYTDHP	CBL_PTK	288:295	Mutation altering degron motif	0.5633
p.E290Q	DO49939	CESC	ICGC	DHEYTDHP	CBL_PTK	288:295	Mutation altering degron motif	0.5633
p.G283D	TCGA-F5-6864	READ	TCGA	DHEYTDHP	CBL_PTK	288:295	Mutation rewiring degron network	0.1944
p.G283D	TCGA-F5-6864	READ	TCGA	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0556
p.G283D	DO36839	READ	ICGC	DHEYTDHP	CBL_PTK	288:295	Mutation rewiring degron network	0.1944
p.G283D	DO36839	READ	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0556
p.E290G	TCGA-L5-A4OJ	ESCA	TCGA	DHEYTDHP	CBL_PTK	288:295	Mutation altering degron motif	0.6087
p.G201S	DO222467	BTCA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1111
p.R287H	DO8898	COAD	ICGC	DHEYTDHP	CBL_PTK	288:295	Mutation rewiring degron network	0.3056
p.G279S	DO50323	ESAD	ICGC	DHEYTDHP	CBL_PTK	288:295	Mutation rewiring degron network	0.0833
p.G279S	DO50323	ESAD	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.1667
p.G279S	DO231563	LINC	ICGC	DHEYTDHP	CBL_PTK	288:295	Mutation rewiring degron network	0.0833
p.G279S	DO231563	LINC	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.1667
p.P226L	DO218068	GACA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.0833
p.P226L	DO233250	GACA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.0833
p.R301Q	DO233730	GACA	ICGC	DHEYTDHP	CBL_PTK	288:295	Mutation rewiring degron network	0.1667
p.D271Y	DO229038	LICA	ICGC	DYR	CBL_MET	271:273	Mutation altering degron motif	0.7325
p.G201C	DO229041	LICA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation rewiring degron network	0.1111
p.R261C	DO23735	LUAD	ICGC	DYR	CBL_MET	271:273	Mutation rewiring degron network	0.0556
p.R215C	DO222644	MELA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	209:217	Mutation altering degron motif	0.719
p.R273H	SIDM00569	Osteosarcoma	GDSC	DYR	CBL_MET	271:273	Mutation altering degron motif	0.8244
p.R273H	SIDM00573	Glioblastoma	GDSC	DYR	CBL_MET	271:273	Mutation altering degron motif	0.8244
p.R273H	SIDM00571	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	271:273	Mutation altering degron motif	0.8244
p.R287C	ACH-000579	Skin Cancer	CCLE	DHEYTDHP	CBL_PTK	288:295	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBMXL3

UniProt ID: Q8N7X1

Entrez ID: 139804

Protein name: RNA-binding motif protein, X-linked-like-3

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RBMXL3 in