DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DHEYTDHP
Uniprot ID:
Q8N7X1
Source protein:
RNA-binding motif protein, X-linked-like-3
Source gene:
RBMXL3
Class:
CBL_PTK
Location:
288:295
E3 ligase:
CBL
DEGRON score:
0.955
ASA_SCORE:
54.625
COIL:
0.7954
CONS_SCORE:
0.3335
DSS_SCORE:
0.6627
HELIX:
0.0636
FCONS_SCORE:
0.9558
RIG_SCORE:
0.678
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E290Q
TCGA-EK-A2PG
CESC
TCGA
DHEYTDHP
CBL_PTK
0.5633
p.E290Q
DO49939
CESC
ICGC
DHEYTDHP
CBL_PTK
0.5633
p.G283D
TCGA-F5-6864
READ
TCGA
DHEYTDHP
CBL_PTK
0.1944
p.G283D
DO36839
READ
ICGC
DHEYTDHP
CBL_PTK
0.1944
p.E290G
TCGA-L5-A4OJ
ESCA
TCGA
DHEYTDHP
CBL_PTK
0.6087
p.R287H
DO8898
COAD
ICGC
DHEYTDHP
CBL_PTK
0.3056
p.G279S
DO50323
ESAD
ICGC
DHEYTDHP
CBL_PTK
0.0833
p.G279S
DO231563
LINC
ICGC
DHEYTDHP
CBL_PTK
0.0833
p.R301Q
DO233730
GACA
ICGC
DHEYTDHP
CBL_PTK
0.1667
p.R287C
ACH-000579
Skin Cancer
CCLE
DHEYTDHP
CBL_PTK
0.3056
Drug responses associated with RBMXL3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DHEYTDHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N7X1
RNA-binding motif protein, X-linked-like-3
CBL_PTK
288:295
DHEYTDHP
CBL
0.955
More...
