DegronMD

Uniprot ID: Q8N7X1

Source protein: RNA-binding motif protein, X-linked-like-3

Source gene: RBMXL3

Class: DEG_APCC_DBOX_1

Location: 209:217

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.996

ASA_SCORE: 69.2889

COIL: 0.7957

CONS_SCORE: 0.2808

DSS_SCORE: 0.6291

HELIX: 0.1177

FCONS_SCORE: 1.0523

RIG_SCORE: 0.6812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R210Q	TCGA-CM-6678	COAD	TCGA	PRSSLARIG	DEG_APCC_DBOX_1	0.7329
p.R210Q	DO10220	COAD	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	0.7329
p.R210Q	SIDM01182	Bladder Carcinoma	GDSC	PRSSLARIG	DEG_APCC_DBOX_1	0.7329
p.G201S	DO222467	BTCA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	0.1111
p.P226L	DO218068	GACA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	0.0833
p.P226L	DO233250	GACA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	0.0833
p.G201C	DO229041	LICA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	0.1111
p.R215C	DO222644	MELA	ICGC	PRSSLARIG	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7X1	RNA-binding motif protein, X-linked-like-3	DEG_APCC_DBOX_1	209:217	PRSSLARIG	APC,CDC20,FZR1	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons