DegronMD - Q92620(DHX38)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D279N	TCGA-19-5956	GBM	TCGA	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.D279N	DO13863	GBM	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1944
p.F39L	TCGA-AC-A23H	BRCA	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1944
p.F39L	DO2401	BRCA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1944
p.P42S	TCGA-AC-A23H	BRCA	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2778
p.P42S	DO2401	BRCA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2778
p.P42S	DO222662	MELA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2778
p.R45C	TCGA-AO-A128	BRCA	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8301
p.R45C	DO5326	BRCA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8301
p.R45C	ACH-001610	Brain Cancer	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8301
p.R1209L	TCGA-BF-A1Q0	SKCM	TCGA	PMTPRRT	DEG_SCF_FBW7_1	1215:1221	Mutation rewiring degron network	0.1667
p.R45H	TCGA-BR-4184	STAD	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	TCGA-BR-A4J2	STAD	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	DO228322	MALY	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	DO38459	STAD	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	DO38328	STAD	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	SIDM01247	Burkitt's Lymphoma	GDSC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	ACH-001636	Lymphoma	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	ACH-002300	Lymphoma	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R45H	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8244
p.R59Q	TCGA-CG-5721	STAD	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1389
p.R59Q	DO38192	STAD	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1389
p.S286T	TCGA-CV-7245	HNSC	TCGA	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6005
p.S286T	DO14322	HNSC	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6005
p.G285W	TCGA-D6-6823	HNSC	TCGA	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6714
p.G285W	DO14222	HNSC	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6714
p.R297H	TCGA-DF-A2KU	UCEC	TCGA	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1667
p.R297H	DO223286	UCEC	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1667
p.P288L	TCGA-DU-8158	LGG	TCGA	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7582
p.P288L	DO22413	LGG	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7582
p.R45S	TCGA-DZ-6133	KIRP	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.7427
p.R45S	TCGA-W3-AA1V	SKCM	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.7427
p.R45S	DO20762	KIRP	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.7427
p.R45S	DO51276	SKCM	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.7427
p.P1207L	TCGA-FW-A3R5	SKCM	TCGA	PMTPRRT	DEG_SCF_FBW7_1	1215:1221	Mutation rewiring degron network	0.1111
p.S234F	TCGA-GF-A3OT	SKCM	TCGA	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation blocking phosphorylation signal	0.5278
p.S234F	DO47288	SKCM	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation blocking phosphorylation signal	0.5278
p.S234F	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation blocking phosphorylation signal	0.5278
p.S234F	ACH-000718	Lung Cancer	CCLE	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation blocking phosphorylation signal	0.5278
p.S234F	NCI-H2291	lung	COSMIC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation blocking phosphorylation signal	0.5278
p.W230L	TCGA-GN-A262	SKCM	TCGA	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.1944
p.W230L	DO37515	SKCM	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.1944
p.E276K	TCGA-KV-A6GE	KIRP	TCGA	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1111
p.E276K	DO48572	KIRP	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1111
p.S34N	TCGA-QS-A5YR	UCEC	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.S34N	DO50081	UCEC	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.S225P	DO48402	BLCA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation altering degron motif	0.5641
p.D217E	DO2473	BRCA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.2778
p.K300M	DO50090	COAD	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.0833
p.A55S	DO228288	LICA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.25
p.R294L	DO228974	LICA	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.25
p.Q216H	DO229036	LICA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.25
p.G295A	DO23374	LINC	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.P288S	DO222363	MELA	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.6752
p.P44S	DO222731	MELA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.5641
p.E493K	DO229130	NKTL	ICGC	DYR	CBL_MET	498:500	Mutation rewiring degron network	0.1944
p.E229K	DO46657	PAAD	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.2222
p.P293Q	DO37851	SKCM	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2778
p.R226G	DO229211	THCA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.3056
p.W277C	DO229224	THCA	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1389
p.V287I	DO42280	UCEC	ICGC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7076
p.R496Q	DO41999	UCEC	ICGC	DYR	CBL_MET	498:500	Mutation rewiring degron network	0.2778
p.A491T	DO41871	UCEC	ICGC	DYR	CBL_MET	498:500	Mutation rewiring degron network	0.1389
p.R289H	SIDM02059	Colorectal Carcinoma	GDSC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7133
p.R289H	SIDM01198	Burkitt's Lymphoma	GDSC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7133
p.R289H	SIDM01157	Other Solid Cancers	GDSC	LGSTPRLS	DEG_SCF_FBW7_1	284:291	Mutation altering degron motif	0.7133
p.T492M	SIDM00684	Glioblastoma	GDSC	DYR	CBL_MET	498:500	Mutation rewiring degron network	0.1667
p.T492M	SIDM00733	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	498:500	Mutation rewiring degron network	0.1667
p.T492M	SIDM01170	Ovarian Carcinoma	GDSC	DYR	CBL_MET	498:500	Mutation rewiring degron network	0.1667
p.R227C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.2778
p.R227C	ACH-002059	Leukemia	CCLE	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.2778
p.R227C	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DSGYGSS	DEG_SCF_TRCP1_1	219:225	Mutation rewiring degron network	0.2778
p.R62Q	SIDM00217	Colorectal Carcinoma	GDSC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.R62Q	ACH-000999	Colon/Colorectal Cancer	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.R62Q	SNU-1040	large intestine	COSMIC	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.R1224H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PMTPRRT	DEG_SCF_FBW7_1	1215:1221	Mutation rewiring degron network	0.25
p.R1224H	ACH-000888	Lung Cancer	CCLE	PMTPRRT	DEG_SCF_FBW7_1	1215:1221	Mutation rewiring degron network	0.25
p.R1224H	NCI-H1793	lung	COSMIC	PMTPRRT	DEG_SCF_FBW7_1	1215:1221	Mutation rewiring degron network	0.25
p.G50R	ACH-001740	Sarcoma	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.6457

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DHX38

UniProt ID: Q92620

Entrez ID: 9785

Protein name: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DHX38 in