DegronMD

Uniprot ID: Q92620

Source protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Source gene: DHX38

Class: DEG_SCF_TRCP1_1

Location: 219:225

E3 ligase: BTRC

DEGRON score: 0.9964

ASA_SCORE: 72.1429

COIL: 0.857

CONS_SCORE: 0.199

DSS_SCORE: 0.5791

HELIX: 0.1014

FCONS_SCORE: 0.8497

RIG_SCORE: 0.5595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S234F	TCGA-GF-A3OT	SKCM	TCGA	DSGYGSS	DEG_SCF_TRCP1_1	0.5278
p.S234F	DO47288	SKCM	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	0.5278
p.S234F	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	DSGYGSS	DEG_SCF_TRCP1_1	0.5278
p.S234F	ACH-000718	Lung Cancer	CCLE	DSGYGSS	DEG_SCF_TRCP1_1	0.5278
p.S234F	NCI-H2291	lung	COSMIC	DSGYGSS	DEG_SCF_TRCP1_1	0.5278
p.W230L	TCGA-GN-A262	SKCM	TCGA	DSGYGSS	DEG_SCF_TRCP1_1	0.1944
p.W230L	DO37515	SKCM	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	0.1944
p.S225P	DO48402	BLCA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	0.5641
p.D217E	DO2473	BRCA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	0.2778
p.Q216H	DO229036	LICA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	0.25
p.E229K	DO46657	PAAD	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	0.2222
p.R226G	DO229211	THCA	ICGC	DSGYGSS	DEG_SCF_TRCP1_1	0.3056
p.R227C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGYGSS	DEG_SCF_TRCP1_1	0.2778
p.R227C	ACH-002059	Leukemia	CCLE	DSGYGSS	DEG_SCF_TRCP1_1	0.2778
p.R227C	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYGSS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92620	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	DEG_SCF_TRCP1_1	219:225	DSGYGSS	BTRC	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons