DegronMD

Uniprot ID: Q92620

Source protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Source gene: DHX38

Class: DEG_APCC_DBOX_1

Location: 44:52

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9712

ASA_SCORE: 66.4556

COIL: 0.6361

CONS_SCORE: 0.2397

DSS_SCORE: 0.3976

HELIX: 0.2499

FCONS_SCORE: 1.0754

RIG_SCORE: 0.7312

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F39L	TCGA-AC-A23H	BRCA	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.1944
p.F39L	DO2401	BRCA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.1944
p.P42S	TCGA-AC-A23H	BRCA	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.2778
p.P42S	DO2401	BRCA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.2778
p.P42S	DO222662	MELA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.2778
p.R45C	TCGA-AO-A128	BRCA	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.8301
p.R45C	DO5326	BRCA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.8301
p.R45C	ACH-001610	Brain Cancer	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	0.8301
p.R45H	TCGA-BR-4184	STAD	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	TCGA-BR-A4J2	STAD	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	DO228322	MALY	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	DO38459	STAD	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	DO38328	STAD	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	SIDM01247	Burkitt's Lymphoma	GDSC	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	ACH-001636	Lymphoma	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	ACH-002300	Lymphoma	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R45H	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PRPSLLGLD	DEG_APCC_DBOX_1	0.8244
p.R59Q	TCGA-CG-5721	STAD	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.1389
p.R59Q	DO38192	STAD	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.1389
p.R45S	TCGA-DZ-6133	KIRP	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.7427
p.R45S	TCGA-W3-AA1V	SKCM	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.7427
p.R45S	DO20762	KIRP	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.7427
p.R45S	DO51276	SKCM	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.7427
p.S34N	TCGA-QS-A5YR	UCEC	TCGA	PRPSLLGLD	DEG_APCC_DBOX_1	0.0556
p.S34N	DO50081	UCEC	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.0556
p.A55S	DO228288	LICA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.25
p.P44S	DO222731	MELA	ICGC	PRPSLLGLD	DEG_APCC_DBOX_1	0.5641
p.R62Q	SIDM00217	Colorectal Carcinoma	GDSC	PRPSLLGLD	DEG_APCC_DBOX_1	0.0556
p.R62Q	ACH-000999	Colon/Colorectal Cancer	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	0.0556
p.R62Q	SNU-1040	large_intestine	COSMIC	PRPSLLGLD	DEG_APCC_DBOX_1	0.0556
p.G50R	ACH-001740	Sarcoma	CCLE	PRPSLLGLD	DEG_APCC_DBOX_1	0.6457

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRPSLLGLD

Degron related mutations and impact score

Drug responses associated with DHX38 mutations

All proteins holding degron of PRPSLLGLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92620	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	DEG_APCC_DBOX_1	44:52	PRPSLLGLD	APC,CDC20,FZR1	0.9712	More...