DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LGSTPRLS
Uniprot ID:
Q92620
Source protein:
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Source gene:
DHX38
Class:
DEG_SCF_FBW7_1
Location:
284:291
E3 ligase:
FBXW7
DEGRON score:
0.9892
ASA_SCORE:
82.75
COIL:
0.8516
CONS_SCORE:
0.2085
DSS_SCORE:
0.5533
HELIX:
0.0738
FCONS_SCORE:
1.0665
RIG_SCORE:
0.6449
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D279N
TCGA-19-5956
GBM
TCGA
LGSTPRLS
DEG_SCF_FBW7_1
0.1944
p.D279N
DO13863
GBM
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.1944
p.S286T
TCGA-CV-7245
HNSC
TCGA
LGSTPRLS
DEG_SCF_FBW7_1
0.6005
p.S286T
DO14322
HNSC
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.6005
p.G285W
TCGA-D6-6823
HNSC
TCGA
LGSTPRLS
DEG_SCF_FBW7_1
0.6714
p.G285W
DO14222
HNSC
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.6714
p.R297H
TCGA-DF-A2KU
UCEC
TCGA
LGSTPRLS
DEG_SCF_FBW7_1
0.1667
p.R297H
DO223286
UCEC
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.1667
p.P288L
TCGA-DU-8158
LGG
TCGA
LGSTPRLS
DEG_SCF_FBW7_1
0.7582
p.P288L
DO22413
LGG
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.7582
p.E276K
TCGA-KV-A6GE
KIRP
TCGA
LGSTPRLS
DEG_SCF_FBW7_1
0.1111
p.E276K
DO48572
KIRP
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.1111
p.K300M
DO50090
COAD
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.0833
p.R294L
DO228974
LICA
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.25
p.G295A
DO23374
LINC
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.2222
p.P288S
DO222363
MELA
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.6752
p.P293Q
DO37851
SKCM
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.2778
p.W277C
DO229224
THCA
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.1389
p.V287I
DO42280
UCEC
ICGC
LGSTPRLS
DEG_SCF_FBW7_1
0.7076
p.R289H
SIDM02059
Colorectal Carcinoma
GDSC
LGSTPRLS
DEG_SCF_FBW7_1
0.7133
p.R289H
SIDM01198
Burkitt's Lymphoma
GDSC
LGSTPRLS
DEG_SCF_FBW7_1
0.7133
p.R289H
SIDM01157
Other Solid Cancers
GDSC
LGSTPRLS
DEG_SCF_FBW7_1
0.7133
Drug responses associated with DHX38 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGSTPRLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92620
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
DEG_SCF_FBW7_1
284:291
LGSTPRLS
FBXW7
0.9892
More...