DegronMD

Uniprot ID: Q92620

Source protein: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Source gene: DHX38

Class: DEG_SCF_FBW7_1

Location: 1215:1221

E3 ligase: FBXW7

DEGRON score: 0.9136

ASA_SCORE: 100.1714

COIL: 0.9057

CONS_SCORE: 0.3031

DSS_SCORE: 0.8277

HELIX: 0.0243

FCONS_SCORE: 0.9949

RIG_SCORE: 0.6812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1209L	TCGA-BF-A1Q0	SKCM	TCGA	PMTPRRT	DEG_SCF_FBW7_1	0.1667
p.P1207L	TCGA-FW-A3R5	SKCM	TCGA	PMTPRRT	DEG_SCF_FBW7_1	0.1111
p.R1224H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PMTPRRT	DEG_SCF_FBW7_1	0.25
p.R1224H	ACH-000888	Lung Cancer	CCLE	PMTPRRT	DEG_SCF_FBW7_1	0.25
p.R1224H	NCI-H1793	lung	COSMIC	PMTPRRT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92620	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	DEG_SCF_FBW7_1	1215:1221	PMTPRRT	FBXW7	0.9136	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons