DegronMD - Q9UJM3(ERRFI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C113R	TCGA-55-8506	LUAD	TCGA	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1944
p.C113R	DO45390	LUAD	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1944
p.V451M	TCGA-A5-A0G1	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.3056
p.V451M	DO42472	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.3056
p.V451M	SIDM00623	Other Blood Cancers	GDSC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.3056
p.V451M	ACH-002339	Leukemia	CCLE	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.3056
p.V451M	Mo-T	haematopoietic and lymphoid tissue	COSMIC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.3056
p.R453H	TCGA-A5-A0G2	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.8244
p.R453H	TCGA-BG-A2L7	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.8244
p.R453H	TCGA-FU-A3HZ	CESC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.8244
p.R453H	DO6308	CESC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.8244
p.R453H	DO42344	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.8244
p.R453H	DO41235	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.8244
p.G448S	TCGA-AP-A1DK	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.2222
p.G448S	DO42033	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.2222
p.S307L	TCGA-B5-A11E	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.7667
p.S307L	TCGA-FW-A3R5	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.7667
p.S307L	DO37406	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.7667
p.S307L	DO41644	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.7667
p.E304A	TCGA-B5-A11E	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.3056
p.E304A	TCGA-B5-A11E	UCEC	TCGA	DYR	CBL_MET	297:299	Mutation rewiring degron network	0.1944
p.E304A	DO41644	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.3056
p.E304A	DO41644	UCEC	ICGC	DYR	CBL_MET	297:299	Mutation rewiring degron network	0.1944
p.H106Y	TCGA-BR-8679	STAD	TCGA	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.6118
p.H106Y	DO47875	STAD	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.6118
p.V460A	TCGA-CG-5721	STAD	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.5825
p.V460A	DO38192	STAD	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.5825
p.E101K	TCGA-CK-4951	COAD	TCGA	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.2778
p.E101K	DO10582	COAD	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.2778
p.P94H	TCGA-DF-A2KN	UCEC	TCGA	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.0833
p.P94H	DO223282	UCEC	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.0833
p.E108D	TCGA-DF-A2KU	UCEC	TCGA	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.5647
p.E108D	TCGA-DU-6392	LGG	TCGA	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.5647
p.E108D	DO22237	LGG	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.5647
p.E108D	DO223286	UCEC	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.5647
p.S457F	TCGA-FR-A7U9	SKCM	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.7982
p.S457F	DO48546	SKCM	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.7982
p.V459A	DO222798	COCA	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.6936
p.L118I	DO228985	LICA	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.0556
p.H455N	DO229025	LICA	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.6312
p.P98S	DO222880	MELA	ICGC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1944
p.I97L	SIDM00962	Chronic Myelogenous Leukemia	GDSC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1667
p.I97L	BV-173	haematopoietic and lymphoid tissue	COSMIC	LGPHEE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1667
p.R315G	SIDM00333	Endometrial Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.R315G	ACH-000988	Endometrial/Uterine Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.R315G	MFE-319	endometrium	COSMIC	VTSST	DEG_SPOP_SBC_1	305:309	Mutation rewiring degron network	0.1667
p.S307P	SIDM01617	Endometrial Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.6752
p.S307P	ACH-000994	Endometrial/Uterine Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	305:309	Mutation altering degron motif	0.6752

Kaplan plot for ERRFI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERRFI1

UniProt ID: Q9UJM3

Entrez ID: 54206

Protein name: ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERRFI1 in