DegronMD

Uniprot ID: Q9UJM3

Source protein: ERBB receptor feedback inhibitor 1

Source gene: ERRFI1

Class: LIG_APCC_ABBA_1

Location: 103:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8686

ASA_SCORE: 78.2833

COIL: 0.8467

CONS_SCORE: 0.4886

DSS_SCORE: 0.4707

HELIX: 0.1002

FCONS_SCORE: 0.7754

RIG_SCORE: 0.653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C113R	TCGA-55-8506	LUAD	TCGA	LGPHEE	LIG_APCC_ABBA_1	0.1944
p.C113R	DO45390	LUAD	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.1944
p.H106Y	TCGA-BR-8679	STAD	TCGA	LGPHEE	LIG_APCC_ABBA_1	0.6118
p.H106Y	DO47875	STAD	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.6118
p.E101K	TCGA-CK-4951	COAD	TCGA	LGPHEE	LIG_APCC_ABBA_1	0.2778
p.E101K	DO10582	COAD	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.2778
p.P94H	TCGA-DF-A2KN	UCEC	TCGA	LGPHEE	LIG_APCC_ABBA_1	0.0833
p.P94H	DO223282	UCEC	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.0833
p.E108D	TCGA-DF-A2KU	UCEC	TCGA	LGPHEE	LIG_APCC_ABBA_1	0.5647
p.E108D	TCGA-DU-6392	LGG	TCGA	LGPHEE	LIG_APCC_ABBA_1	0.5647
p.E108D	DO22237	LGG	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.5647
p.E108D	DO223286	UCEC	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.5647
p.L118I	DO228985	LICA	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.0556
p.P98S	DO222880	MELA	ICGC	LGPHEE	LIG_APCC_ABBA_1	0.1944
p.I97L	SIDM00962	Chronic Myelogenous Leukemia	GDSC	LGPHEE	LIG_APCC_ABBA_1	0.1667
p.I97L	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	LGPHEE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJM3	ERBB receptor feedback inhibitor 1	LIG_APCC_ABBA_1	103:108	LGPHEE	APC,CDC20,FZR1	0.8686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons