DegronMD

Uniprot ID: Q9UJM3

Source protein: ERBB receptor feedback inhibitor 1

Source gene: ERRFI1

Class: DEG_APCC_DBOX_1

Location: 452:460

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9241

ASA_SCORE: 93.7

COIL: 0.544

CONS_SCORE: 0.629

DSS_SCORE: 0.6509

HELIX: 0.1578

FCONS_SCORE: 1.2789

RIG_SCORE: 0.76

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R453H	TCGA-A5-A0G2	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	0.8244
p.R453H	TCGA-BG-A2L7	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	0.8244
p.R453H	TCGA-FU-A3HZ	CESC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	0.8244
p.R453H	DO6308	CESC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.8244
p.R453H	DO42344	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.8244
p.R453H	DO41235	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.8244
p.S457F	TCGA-FR-A7U9	SKCM	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	0.7982
p.S457F	DO48546	SKCM	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.7982
p.V459A	DO222798	COCA	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.6936
p.H455N	DO229025	LICA	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.6312
p.V460A	TCGA-CG-5721	STAD	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	0.5825
p.V460A	DO38192	STAD	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.5825
p.V451M	TCGA-A5-A0G1	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	0.3056
p.V451M	DO42472	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.3056
p.V451M	SIDM00623	Other Blood Cancers	GDSC	KRKHLSYVV	DEG_APCC_DBOX_1	0.3056
p.V451M	ACH-002339	Leukemia	CCLE	KRKHLSYVV	DEG_APCC_DBOX_1	0.3056
p.V451M	Mo-T	haematopoietic_and_lymphoid_tissue	COSMIC	KRKHLSYVV	DEG_APCC_DBOX_1	0.3056
p.G448S	TCGA-AP-A1DK	UCEC	TCGA	KRKHLSYVV	DEG_APCC_DBOX_1	0.2222
p.G448S	DO42033	UCEC	ICGC	KRKHLSYVV	DEG_APCC_DBOX_1	0.2222

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_APCC_DBOX_1	452:460	KRKHLSYVV	APC,CDC20,FZR1	0.9241	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons