DegronMD - P51805(PLXNA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1301A	TCGA-06-5416	GBM	TCGA	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.3056
p.T1301A	DO10880	GBM	ICGC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.3056
p.E897K	TCGA-97-8176	LUAD	TCGA	EMEESLVPSP	DEG_COP1_1	897:906	Mutation altering degron motif	0.7022
p.E897K	DO218933	LUAD	ICGC	EMEESLVPSP	DEG_COP1_1	897:906	Mutation altering degron motif	0.7022
p.F1308L	TCGA-XF-A9SY	BLCA	TCGA	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.1111
p.F1308L	DO51918	BLCA	ICGC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.1111
p.P1295S	TCGA-YD-A9TA	SKCM	TCGA	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.25
p.P1295S	DO219503	SKCM	ICGC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.25
p.V895M	DO233882	GACA	ICGC	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.2778
p.G916S	DO50970	LICA	ICGC	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.0556
p.G916V	DO45083	LINC	ICGC	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.0556
p.G1310V	DO232064	ORCA	ICGC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.0556
p.R1305C	DO51484	PACA	ICGC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.1944
p.P1309L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.0833
p.P1309L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.0833
p.P1309L	SIDM00248	Gastric Carcinoma	GDSC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.0833
p.P1309L	ACH-000758	Gastric Cancer	CCLE	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.0833
p.P1309L	ACH-000995	Leukemia	CCLE	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.0833
p.P1309L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.0833
p.P907L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.3056
p.P907L	LC-2-ad	lung	COSMIC	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.3056
p.Y888H	SIDM01608	Endometrial Carcinoma	GDSC	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.0833
p.Y888H	ACH-000990	Endometrial/Uterine Cancer	CCLE	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.0833
p.V915L	ACH-000231	Brain Cancer	CCLE	EMEESLVPSP	DEG_COP1_1	897:906	Mutation rewiring degron network	0.0833
p.V903G	ACH-000501	Colon/Colorectal Cancer	CCLE	EMEESLVPSP	DEG_COP1_1	897:906	Mutation altering degron motif	0.7532
p.R1305H	ACH-000854	Myeloma	CCLE	DYR	CBL_MET	1298:1300	Mutation rewiring degron network	0.1944

Kaplan plot for PLXNA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLXNA3

UniProt ID: P51805

Entrez ID: 55558

Protein name: Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLXNA3 in