DegronMD

Uniprot ID: P51805

Source protein: Plexin-A3

Source gene: PLXNA3

Class: DEG_COP1_1

Location: 897:906

E3 ligase: COP1

DEGRON score: 0.986

ASA_SCORE: 79.93

COIL: 0.7616

CONS_SCORE: 0.3942

DSS_SCORE: 0.3478

HELIX: 0.0222

FCONS_SCORE: 0.7502

RIG_SCORE: 0.7197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E897K	TCGA-97-8176	LUAD	TCGA	EMEESLVPSP	DEG_COP1_1	0.7022
p.E897K	DO218933	LUAD	ICGC	EMEESLVPSP	DEG_COP1_1	0.7022
p.V895M	DO233882	GACA	ICGC	EMEESLVPSP	DEG_COP1_1	0.2778
p.G916S	DO50970	LICA	ICGC	EMEESLVPSP	DEG_COP1_1	0.0556
p.G916V	DO45083	LINC	ICGC	EMEESLVPSP	DEG_COP1_1	0.0556
p.P907L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	EMEESLVPSP	DEG_COP1_1	0.3056
p.P907L	LC-2-ad	lung	COSMIC	EMEESLVPSP	DEG_COP1_1	0.3056
p.Y888H	SIDM01608	Endometrial Carcinoma	GDSC	EMEESLVPSP	DEG_COP1_1	0.0833
p.Y888H	ACH-000990	Endometrial/Uterine Cancer	CCLE	EMEESLVPSP	DEG_COP1_1	0.0833
p.V915L	ACH-000231	Brain Cancer	CCLE	EMEESLVPSP	DEG_COP1_1	0.0833
p.V903G	ACH-000501	Colon/Colorectal Cancer	CCLE	EMEESLVPSP	DEG_COP1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51805	Plexin-A3	DEG_COP1_1	897:906	EMEESLVPSP	COP1	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons