DegronMD - P28370(SMARCA1)

FUNCTION: [Isoform 1]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:28801535}.; FUNCTION: [Isoform 2]: Helicase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:15310751, PubMed:14609955, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:15310751, PubMed:14609955, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:15310751, PubMed:14609955, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). {ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:16740656, ECO:0000269|PubMed:28801535}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I139M	TCGA-34-5239	LUSC	TCGA	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.2222
p.I139M	DO27660	LUSC	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.2222
p.T149I	TCGA-34-5240	LUSC	TCGA	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.2222
p.T149I	DO26563	LUSC	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.2222
p.D154Y	TCGA-A5-A0GP	UCEC	TCGA	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.0833
p.D154Y	DO41109	UCEC	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.0833
p.R148H	TCGA-AG-3892	READ	TCGA	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.25
p.R148H	DO232761	PBCA	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.25
p.R148H	DO36394	READ	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.25
p.R145S	TCGA-D3-A3CE	SKCM	TCGA	DYR	CBL_MET	143:145	Mutation altering degron motif	0.7427
p.R145S	DO37405	SKCM	ICGC	DYR	CBL_MET	143:145	Mutation altering degron motif	0.7427
p.Q136H	TCGA-DF-A2KS	UCEC	TCGA	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.1389
p.Q136H	DO223285	UCEC	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.1389
p.R145C	TCGA-E9-A1RB	BRCA	TCGA	DYR	CBL_MET	143:145	Mutation altering degron motif	0.8301
p.R145C	DO3757	BRCA	ICGC	DYR	CBL_MET	143:145	Mutation altering degron motif	0.8301
p.I139V	DO233939	GACA	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.2222
p.A141D	DO229027	LICA	ICGC	DYR	CBL_MET	143:145	Mutation rewiring degron network	0.2778

Kaplan plot for SMARCA1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCA1

UniProt ID: P28370

Entrez ID: 6594

Protein name: Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SMARCA1 in