DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DYR
Uniprot ID:
P28370
Source protein:
Probable global transcription activator SNF2L1
Source gene:
SMARCA1
Class:
CBL_MET
Location:
143:145
E3 ligase:
CBL
DEGRON score:
0.74
ASA_SCORE:
119
COIL:
0.571
CONS_SCORE:
0.3249
DSS_SCORE:
0.6004
HELIX:
0.4047
FCONS_SCORE:
0.9012
RIG_SCORE:
0.6929
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R145C
TCGA-E9-A1RB
BRCA
TCGA
DYR
CBL_MET
0.8301
p.R145C
DO3757
BRCA
ICGC
DYR
CBL_MET
0.8301
p.R145S
TCGA-D3-A3CE
SKCM
TCGA
DYR
CBL_MET
0.7427
p.R145S
DO37405
SKCM
ICGC
DYR
CBL_MET
0.7427
p.A141D
DO229027
LICA
ICGC
DYR
CBL_MET
0.2778
p.R148H
TCGA-AG-3892
READ
TCGA
DYR
CBL_MET
0.25
p.R148H
DO232761
PBCA
ICGC
DYR
CBL_MET
0.25
p.R148H
DO36394
READ
ICGC
DYR
CBL_MET
0.25
p.I139M
TCGA-34-5239
LUSC
TCGA
DYR
CBL_MET
0.2222
p.I139M
DO27660
LUSC
ICGC
DYR
CBL_MET
0.2222
p.T149I
TCGA-34-5240
LUSC
TCGA
DYR
CBL_MET
0.2222
p.T149I
DO26563
LUSC
ICGC
DYR
CBL_MET
0.2222
p.I139V
DO233939
GACA
ICGC
DYR
CBL_MET
0.2222
p.Q136H
TCGA-DF-A2KS
UCEC
TCGA
DYR
CBL_MET
0.1389
p.Q136H
DO223285
UCEC
ICGC
DYR
CBL_MET
0.1389
p.D154Y
TCGA-A5-A0GP
UCEC
TCGA
DYR
CBL_MET
0.0833
p.D154Y
DO41109
UCEC
ICGC
DYR
CBL_MET
0.0833
Showing 1 to 17 of 17 entries
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Drug responses associated with SMARCA1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DYR
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y2I7
1-phosphatidylinositol 3-phosphate 5-kinase
CBL_MET
1154:1156
DYR
CBL
0.9899
More...
P62333
26S proteasome regulatory subunit 10B
CBL_MET
11:13
DYR
CBL
0.5589
More...
Q96A35
39S ribosomal protein L24, mitochondrial
CBL_MET
103:105
DYR
CBL
0.8186
More...
Q9P2N4
A disintegrin and metalloproteinase with thrombospondin motifs 9
CBL_MET
1313:1315
DYR
CBL
0.9337
More...
Q12802
A-kinase anchor protein 13
CBL_MET
823:825
DYR
CBL
0.8159
More...
Q96K21
Abscission/NoCut checkpoint regulator
CBL_MET
348:350
DYR
CBL
0.5257
More...
P40145
Adenylate cyclase type 8
CBL_MET
1148:1150
DYR
CBL
0.7268
More...
P51825
AF4/FMR2 family member 1
CBL_MET
316:318
DYR
CBL
0.9069
More...
Q9P0K7
Ankycorbin
CBL_MET
661:663
DYR
CBL
0.6245
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Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
864:866
DYR
CBL
0.5334
More...
Q6UB99
Ankyrin repeat domain-containing protein 11
CBL_MET
899:901
DYR
CBL
0.7809
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Q96NW4
Ankyrin repeat domain-containing protein 27
CBL_MET
666:668
DYR
CBL
0.9069
More...
Q8N944
APC membrane recruitment protein 3
CBL_MET
128:130
DYR
CBL
0.9544
More...
Q9BZC7
ATP-binding cassette sub-family A member 2
CBL_MET
1395:1397
DYR
CBL
0.9909
More...
Q08211
ATP-dependent RNA helicase A
CBL_MET
1233:1235
DYR
CBL
0.9757
More...
O00571
ATP-dependent RNA helicase DDX3X
CBL_MET
601:603
DYR
CBL
0.9982
More...
O15523
ATP-dependent RNA helicase DDX3Y
CBL_MET
599:601
DYR
CBL
0.9998
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
56:58
DYR
CBL
0.7315
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
60:62
DYR
CBL
0.9219
More...
Q9NYF8
Bcl-2-associated transcription factor 1
CBL_MET
407:409
DYR
CBL
0.8675
More...
A2AJT9
BCLAF1 and THRAP3 family member 3
CBL_MET
280:282
DYR
CBL
0.8797
More...
Q9NWK9
Box C/D snoRNA protein 1
CBL_MET
277:279
DYR
CBL
0.8233
More...
Q9NSI6
Bromodomain and WD repeat-containing protein 1
CBL_MET
563:565
DYR
CBL
0.9622
More...
P25440
Bromodomain-containing protein 2
CBL_MET
407:409
DYR
CBL
0.9586
More...
Q2TAL6
Brorin
CBL_MET
149:151
DYR
CBL
0.987
More...
Showing 1 to 25 of 231 entries
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