DegronMD - Q9Y5F7(PCDHGC4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G188S	TCGA-05-4250	LUAD	TCGA	SDGSLVPEL	DEG_COP1_1	186:194	Mutation altering degron motif	0.5882
p.G188S	TCGA-86-8055	LUAD	TCGA	SDGSLVPEL	DEG_COP1_1	186:194	Mutation altering degron motif	0.5882
p.G188S	DO25554	LUAD	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation altering degron motif	0.5882
p.G188S	DO24457	LUAD	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation altering degron motif	0.5882
p.R209H	TCGA-19-5956	GBM	TCGA	DYR	CBL_MET	207:209	Mutation altering degron motif	0.8244
p.R209H	TCGA-QQ-A8VF	SARC	TCGA	DYR	CBL_MET	207:209	Mutation altering degron motif	0.8244
p.R209H	DO13863	GBM	ICGC	DYR	CBL_MET	207:209	Mutation altering degron motif	0.8244
p.R209H	DO220258	SARC	ICGC	DYR	CBL_MET	207:209	Mutation altering degron motif	0.8244
p.R185H	TCGA-2W-A8YY	CESC	TCGA	SDGSLVPEL	DEG_COP1_1	186:194	Mutation rewiring degron network	0.3056
p.R185H	DO223732	CESC	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation rewiring degron network	0.3056
p.R538W	TCGA-2W-A8YY	CESC	TCGA	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.1667
p.R538W	DO223732	CESC	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.1667
p.D187N	TCGA-2Z-A9J7	KIRP	TCGA	SDGSLVPEL	DEG_COP1_1	186:194	Mutation altering degron motif	0.6932
p.D187N	DO219658	KIRP	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation altering degron motif	0.6932
p.R552C	TCGA-A5-A2K5	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	TCGA-AP-A056	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	TCGA-BR-8680	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	TCGA-EO-A22X	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	DO36881	READ	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	DO47769	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	DO43907	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	DO43971	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552C	DO41379	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.L212M	TCGA-AG-A002	READ	TCGA	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.25
p.D675Y	TCGA-AX-A2HC	UCEC	TCGA	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.7325
p.D675Y	DO41572	UCEC	ICGC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.7325
p.R209C	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	207:209	Mutation altering degron motif	0.8301
p.R209C	DO223286	UCEC	ICGC	DYR	CBL_MET	207:209	Mutation altering degron motif	0.8301
p.D557Y	TCGA-DK-AA6U	BLCA	TCGA	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.0833
p.D557Y	DO219008	BLCA	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.0833
p.D216N	TCGA-EY-A1GF	UCEC	TCGA	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.1389
p.D216N	DO41704	UCEC	ICGC	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.1389
p.D675A	TCGA-F5-6814	READ	TCGA	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.7793
p.D675A	DO36556	READ	ICGC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.7793
p.R540W	TCGA-FS-A1YY	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R540W	DO37415	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.V673A	TCGA-FU-A3HZ	CESC	TCGA	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.6936
p.V673A	DO6308	CESC	ICGC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.6936
p.L661P	TCGA-XF-A9T6	BLCA	TCGA	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.1944
p.L661P	DO51926	BLCA	ICGC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.1944
p.D201N	TCGA-XK-AAIW	PRAD	TCGA	SDGSLVPEL	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1389
p.D201N	TCGA-XK-AAIW	PRAD	TCGA	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.1667
p.D201N	DO51407	PRAD	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1389
p.D201N	DO51407	PRAD	ICGC	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.1667
p.S664F	TCGA-YD-A9TA	SKCM	TCGA	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.2778
p.S664F	DO219503	SKCM	ICGC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.2778
p.D557H	DO228728	EOPC	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.0833
p.P544L	DO234389	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation altering degron motif	0.7582
p.P544L	DO219873	SKCA	ICGC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation altering degron motif	0.7582
p.P904T	DO233115	GACA	ICGC	DYR	CBL_MET	896:898	Mutation rewiring degron network	0.1667
p.E193A	DO233791	GACA	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation altering degron motif	0.7701
p.V659F	DO228976	LICA	ICGC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.1389
p.A179S	DO229019	LICA	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1389
p.K204N	DO229036	LICA	ICGC	SDGSLVPEL	DEG_COP1_1	186:194	Mutation substituting flanking lysine	0.1667
p.K204N	DO229036	LICA	ICGC	DYR	CBL_MET	207:209	Mutation substituting flanking lysine	0.3611
p.V894M	DO25554	LUAD	ICGC	DYR	CBL_MET	896:898	Mutation rewiring degron network	0.2778
p.V894M	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	896:898	Mutation rewiring degron network	0.2778
p.V901G	DO28089	OV	ICGC	DYR	CBL_MET	896:898	Mutation rewiring degron network	0.25
p.T890A	DO48918	PBCA	ICGC	DYR	CBL_MET	896:898	Mutation rewiring degron network	0.1667
p.R898H	DO41871	UCEC	ICGC	DYR	CBL_MET	896:898	Mutation altering degron motif	0.8244
p.R898C	DO42568	UCEC	ICGC	DYR	CBL_MET	896:898	Mutation altering degron motif	0.8301
p.S680L	SIDM00080	Melanoma	GDSC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.2222
p.S680L	ACH-000730	Skin Cancer	CCLE	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.2222
p.S680L	SK-MEL-5	skin	COSMIC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation rewiring degron network	0.2222
p.A537V	SIDM00683	Prostate Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.1389
p.A537V	LNCaP-Clone-FGC	prostate	COSMIC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.1389
p.Q205K	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.2778
p.Q205K	ACH-002101	Lung Cancer	CCLE	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.2778
p.Q205K	EMC-BAC-1	lung	COSMIC	DYR	CBL_MET	207:209	Mutation rewiring degron network	0.2778
p.R552H	SIDM00567	Other Solid Cancers	GDSC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552H	SIDM00165	Other Solid Cancers	GDSC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552H	ACH-000407	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.R552H	ACH-000776	Brain Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.N542I	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2778
p.N542I	ACH-000916	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2778
p.N542I	NCI-H1573	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2778
p.L676I	SIDM01018	Hodgkin's Lymphoma	GDSC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.6063
p.L676I	ACH-000815	Lymphoma	CCLE	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.6063
p.L676I	KM-H2	haematopoietic and lymphoid tissue	COSMIC	EEDTHPVVPDL	DEG_COP1_1	666:676	Mutation altering degron motif	0.6063
p.S546R	ACH-000872	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	544:548	Mutation altering degron motif	0.8538

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGC4

UniProt ID: Q9Y5F7

Entrez ID: 56098

Protein name: Protocadherin gamma-C4 (PCDH-gamma-C4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGC4 in