DegronMD

Uniprot ID: Q9Y5F7

Source protein: Protocadherin gamma-C4

Source gene: PCDHGC4

Class: DEG_COP1_1

Location: 186:194

E3 ligase: COP1

DEGRON score: 0.8231

ASA_SCORE: 51.7444

COIL: 0.4486

CONS_SCORE: 0.7462

DSS_SCORE: 0.3156

HELIX: 0.0058

FCONS_SCORE: 1.1888

RIG_SCORE: 0.7493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G188S	TCGA-05-4250	LUAD	TCGA	SDGSLVPEL	DEG_COP1_1	0.5882
p.G188S	TCGA-86-8055	LUAD	TCGA	SDGSLVPEL	DEG_COP1_1	0.5882
p.G188S	DO25554	LUAD	ICGC	SDGSLVPEL	DEG_COP1_1	0.5882
p.G188S	DO24457	LUAD	ICGC	SDGSLVPEL	DEG_COP1_1	0.5882
p.R185H	TCGA-2W-A8YY	CESC	TCGA	SDGSLVPEL	DEG_COP1_1	0.3056
p.R185H	DO223732	CESC	ICGC	SDGSLVPEL	DEG_COP1_1	0.3056
p.D187N	TCGA-2Z-A9J7	KIRP	TCGA	SDGSLVPEL	DEG_COP1_1	0.6932
p.D187N	DO219658	KIRP	ICGC	SDGSLVPEL	DEG_COP1_1	0.6932
p.D201N	TCGA-XK-AAIW	PRAD	TCGA	SDGSLVPEL	DEG_COP1_1	0.1389
p.D201N	DO51407	PRAD	ICGC	SDGSLVPEL	DEG_COP1_1	0.1389
p.E193A	DO233791	GACA	ICGC	SDGSLVPEL	DEG_COP1_1	0.7701
p.A179S	DO229019	LICA	ICGC	SDGSLVPEL	DEG_COP1_1	0.1389
p.K204N	DO229036	LICA	ICGC	SDGSLVPEL	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5F7	Protocadherin gamma-C4	DEG_COP1_1	186:194	SDGSLVPEL	COP1	0.8231	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons