DegronMD

Uniprot ID: Q9Y5F7

Source protein: Protocadherin gamma-C4

Source gene: PCDHGC4

Class: DEG_COP1_1

Location: 666:676

E3 ligase: COP1

DEGRON score: 0.5546

ASA_SCORE: 70.5818

COIL: 0.7724

CONS_SCORE: 0.637

DSS_SCORE: 0.4655

HELIX: 0.046

FCONS_SCORE: 1.1855

RIG_SCORE: 0.751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D675Y	TCGA-AX-A2HC	UCEC	TCGA	EEDTHPVVPDL	DEG_COP1_1	0.7325
p.D675Y	DO41572	UCEC	ICGC	EEDTHPVVPDL	DEG_COP1_1	0.7325
p.D675A	TCGA-F5-6814	READ	TCGA	EEDTHPVVPDL	DEG_COP1_1	0.7793
p.D675A	DO36556	READ	ICGC	EEDTHPVVPDL	DEG_COP1_1	0.7793
p.V673A	TCGA-FU-A3HZ	CESC	TCGA	EEDTHPVVPDL	DEG_COP1_1	0.6936
p.V673A	DO6308	CESC	ICGC	EEDTHPVVPDL	DEG_COP1_1	0.6936
p.L661P	TCGA-XF-A9T6	BLCA	TCGA	EEDTHPVVPDL	DEG_COP1_1	0.1944
p.L661P	DO51926	BLCA	ICGC	EEDTHPVVPDL	DEG_COP1_1	0.1944
p.S664F	TCGA-YD-A9TA	SKCM	TCGA	EEDTHPVVPDL	DEG_COP1_1	0.2778
p.S664F	DO219503	SKCM	ICGC	EEDTHPVVPDL	DEG_COP1_1	0.2778
p.V659F	DO228976	LICA	ICGC	EEDTHPVVPDL	DEG_COP1_1	0.1389
p.S680L	SIDM00080	Melanoma	GDSC	EEDTHPVVPDL	DEG_COP1_1	0.2222
p.S680L	ACH-000730	Skin Cancer	CCLE	EEDTHPVVPDL	DEG_COP1_1	0.2222
p.S680L	SK-MEL-5	skin	COSMIC	EEDTHPVVPDL	DEG_COP1_1	0.2222
p.L676I	SIDM01018	Hodgkin's Lymphoma	GDSC	EEDTHPVVPDL	DEG_COP1_1	0.6063
p.L676I	ACH-000815	Lymphoma	CCLE	EEDTHPVVPDL	DEG_COP1_1	0.6063
p.L676I	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	EEDTHPVVPDL	DEG_COP1_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5F7	Protocadherin gamma-C4	DEG_COP1_1	666:676	EEDTHPVVPDL	COP1	0.5546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons