DegronMD - Q9UER7(DAXX)

FUNCTION: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P160T	TCGA-12-0775	GBM	TCGA	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.P160T	DO14133	GBM	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.P670H	TCGA-13-1484	OV	TCGA	ADSST	DEG_SPOP_SBC_1	680:684	Mutation rewiring degron network	0.0556
p.P670H	DO29006	OV	ICGC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation rewiring degron network	0.0556
p.S402F	TCGA-98-A538	LUSC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation blocking phosphorylation signal	0.5
p.S402F	DO219177	LUSC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation blocking phosphorylation signal	0.5
p.L413F	TCGA-A3-A8OU	KIRC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.587
p.L413F	DO219231	KIRC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.587
p.K512E	TCGA-AJ-A3EK	UCEC	TCGA	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation blocking ubiquitination signal	0.6944
p.K512E	DO41584	UCEC	ICGC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation blocking ubiquitination signal	0.6944
p.V617I	TCGA-AP-A056	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation rewiring degron network	0.1944
p.V617I	DO43971	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation rewiring degron network	0.1944
p.E410D	TCGA-AP-A1DV	UCEC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.2778
p.E410D	TCGA-AP-A1DV	UCEC	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.2222
p.E410D	DO43186	UCEC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.2778
p.E410D	DO43186	UCEC	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.2222
p.S612T	TCGA-AX-A1CE	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation altering degron motif	0.6005
p.S612T	DO42280	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation altering degron motif	0.6005
p.S682C	TCGA-B0-5115	KIRC	TCGA	ADSST	DEG_SPOP_SBC_1	680:684	Mutation altering degron motif	0.7541
p.S682C	DO18761	KIRC	ICGC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation altering degron motif	0.7541
p.S415F	TCGA-BP-4987	KIRC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.9093
p.S415F	TCGA-BP-4987	KIRC	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.9093
p.S415F	DO19088	KIRC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.9093
p.S415F	DO19088	KIRC	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.9093
p.R526H	TCGA-BR-4184	STAD	TCGA	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.R526H	TCGA-EA-A3HU	CESC	TCGA	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.R526H	DO6320	CESC	ICGC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.R526H	DO233864	GACA	ICGC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.R526H	DO38328	STAD	ICGC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.I527V	TCGA-BR-8680	STAD	TCGA	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1389
p.I527V	DO47769	STAD	ICGC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1389
p.H404Y	TCGA-CK-4951	COAD	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1111
p.H404Y	TCGA-CK-4951	COAD	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.0556
p.H404Y	TCGA-GN-A26A	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1111
p.H404Y	TCGA-GN-A26A	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.0556
p.H404Y	DO10582	COAD	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1111
p.H404Y	DO10582	COAD	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.0556
p.H404Y	DO37861	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1111
p.H404Y	DO37861	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.0556
p.S671F	TCGA-CN-A6V1	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	680:684	Mutation blocking phosphorylation signal	0.5278
p.S671F	DO52048	HNSC	ICGC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation blocking phosphorylation signal	0.5278
p.G416C	TCGA-D3-A2JP	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.76
p.G416C	TCGA-D3-A2JP	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.76
p.G416C	DO47407	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.76
p.G416C	DO47407	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.76
p.A149V	TCGA-DF-A2KU	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.5825
p.A149V	DO223286	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.5825
p.R685M	TCGA-DU-6392	LGG	TCGA	ADSST	DEG_SPOP_SBC_1	680:684	Mutation rewiring degron network	0.3056
p.R685M	DO22237	LGG	ICGC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation rewiring degron network	0.3056
p.P155S	TCGA-EE-A29L	SKCM	TCGA	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.P155S	DO222599	MELA	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.P155S	DO37835	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.A47V	TCGA-EE-A2MJ	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1944
p.A47V	DO38099	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1944
p.V348I	TCGA-EY-A215	UCEC	TCGA	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.25
p.V348I	TCGA-LD-A74U	BRCA	TCGA	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.25
p.V348I	DO49025	BRCA	ICGC	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.25
p.V348I	DO42665	UCEC	ICGC	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.25
p.D407V	TCGA-FS-A1Z3	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1944
p.D407V	TCGA-FS-A1Z3	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.1389
p.D407V	DO37635	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1944
p.D407V	DO37635	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.1389
p.S41F	TCGA-FW-A3R5	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.9093
p.S41F	DO37406	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.9093
p.G421E	TCGA-GN-A263	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.2222
p.G421E	TCGA-GN-A263	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.3056
p.G421E	DO37766	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.2222
p.G421E	DO37766	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.3056
p.M607V	TCGA-HC-7818	PRAD	TCGA	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation rewiring degron network	0.3056
p.M607V	DO36338	PRAD	ICGC	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation rewiring degron network	0.3056
p.L143M	TCGA-OL-A6VQ	BRCA	TCGA	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944
p.L143M	DO51214	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944
p.P161R	TCGA-XF-A9SP	BLCA	TCGA	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.P161R	DO223598	BLCA	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.T684M	DO225313	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation altering degron motif	0.7423
p.T151N	DO1123	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7055
p.E602D	DO222762	COCA	ICGC	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation rewiring degron network	0.1667
p.C338Y	DO233941	GACA	ICGC	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.1944
p.A149T	DO220878	MELA	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.6028
p.P678L	DO222731	MELA	ICGC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation rewiring degron network	0.2778
p.N153S	DO32819	PACA	ICGC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.N153S	SIDM01136	Pancreatic Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.N153S	ACH-000417	Pancreatic Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.N153S	PANC-08-13	pancreas	COSMIC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.E417G	DO35654	PBCA	ICGC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.7199
p.E417G	DO35654	PBCA	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.6087
p.S671P	DO229232	THCA	ICGC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation blocking phosphorylation signal	0.5278
p.S671P	SIDM01045	Endometrial Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation blocking phosphorylation signal	0.5278
p.S671P	ACH-000978	Endometrial/Uterine Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	680:684	Mutation blocking phosphorylation signal	0.5278
p.S671P	EN	endometrium	COSMIC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation blocking phosphorylation signal	0.5278
p.V617F	DO229248	THCA	ICGC	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation rewiring degron network	0.1944
p.D687V	SIDM01314	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation rewiring degron network	0.25
p.N523S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.25
p.N523S	ACH-000981	Leukemia	CCLE	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.25
p.N523S	DND-41	haematopoietic and lymphoid tissue	COSMIC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.25
p.R526C	SIDM01043	Other Sarcomas	GDSC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.R526C	ACH-000913	Endometrial/Uterine Cancer	CCLE	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.R526C	ESS-1	endometrium	COSMIC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation rewiring degron network	0.1667
p.K140E	SIDM00156	Neuroblastoma	GDSC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation substituting flanking lysine	0.2222
p.K140E	NB7	autonomic ganglia	COSMIC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation substituting flanking lysine	0.2222
p.G416V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.7532
p.G416V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.7532
p.G416V	ACH-000929	Lung Cancer	CCLE	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.7532
p.G416V	ACH-000929	Lung Cancer	CCLE	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.7532
p.G416V	NCI-H2110	lung	COSMIC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation altering degron motif	0.7532
p.G416V	NCI-H2110	lung	COSMIC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation altering degron motif	0.7532
p.T162I	SIDM00876	Non-Cancerous	GDSC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T162I	SIDM00877	Breast Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T162I	ACH-000196	Breast Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T162I	ACH-002374	Non-Cancerous	CCLE	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.M422V	SIDM00068	Colorectal Carcinoma	GDSC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1944
p.M422V	SIDM00068	Colorectal Carcinoma	GDSC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.2778
p.M422V	ACH-002394	Colon/Colorectal Cancer	CCLE	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.1944
p.M422V	ACH-002394	Colon/Colorectal Cancer	CCLE	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.2778
p.A32T	SIDM00217	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1667
p.A32T	ACH-000999	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1667
p.A32T	SNU-1040	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1667
p.C427Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.0556
p.C427Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.1389
p.C427Y	ACH-000937	Leukemia	CCLE	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.0556
p.C427Y	ACH-000937	Leukemia	CCLE	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.1389
p.C427Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.0556
p.C427Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.1389
p.P155T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.P155T	ACH-000964	Leukemia	CCLE	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.S515N	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation altering degron motif	0.7069
p.S515N	ACH-000925	Lung Cancer	CCLE	SRSSGE	DEG_Kelch_Keap1_1	515:520	Mutation altering degron motif	0.7069
p.D349H	SIDM00162	Biliary Tract Carcinoma	GDSC	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.2222
p.D349H	ACH-000268	Bile Duct Cancer	CCLE	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.2222
p.S683Y	ACH-000887	Brain Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	680:684	Mutation altering degron motif	0.8231
p.S138P	ACH-000928	Endometrial/Uterine Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.S138P	COR-L95	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.P29L	ACH-002396	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.P29L	Sarc9371	bone	COSMIC	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.P29S	ACH-002396	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.P29S	Sarc9371	bone	COSMIC	APSSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.C673Y	U-CH2	bone	COSMIC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation rewiring degron network	0.1389
p.S145F	Mewo	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.S621N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VSSTS	DEG_SPOP_SBC_1	608:612	Mutation rewiring degron network	0.0833
p.A151G	SHP-77	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.754
p.C352Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.1389
p.G341V	NCI-H2110	lung	COSMIC	DYR	CBL_MET	343:345	Mutation rewiring degron network	0.2778
p.A411V	MDA-MB-361	breast	COSMIC	SLDSGE	DEG_Kelch_Keap1_1	412:417	Mutation rewiring degron network	0.3056
p.A411V	MDA-MB-361	breast	COSMIC	DSGEGPS	DEG_SCF_TRCP1_1	414:420	Mutation rewiring degron network	0.25
p.H683Y	MFE-319	endometrium	COSMIC	ADSST	DEG_SPOP_SBC_1	680:684	Mutation altering degron motif	0.7229

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DAXX

UniProt ID: Q9UER7

Entrez ID: 1616

Protein name: Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DAXX in