DegronMD

Uniprot ID: Q9UER7

Source protein: Death domain-associated protein 6

Source gene: DAXX

Class: DEG_SCF_TRCP1_1

Location: 414:420

E3 ligase: BTRC

DEGRON score: 0.9984

ASA_SCORE: 82.0571

COIL: 0.9161

CONS_SCORE: 0.3785

DSS_SCORE: 0.8211

HELIX: 0.066

FCONS_SCORE: 1.0611

RIG_SCORE: 0.5002

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S415F	TCGA-BP-4987	KIRC	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	0.9093
p.S415F	DO19088	KIRC	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.9093
p.G416C	TCGA-D3-A2JP	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	0.76
p.G416C	DO47407	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.76
p.G416V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGEGPS	DEG_SCF_TRCP1_1	0.7532
p.G416V	ACH-000929	Lung Cancer	CCLE	DSGEGPS	DEG_SCF_TRCP1_1	0.7532
p.G416V	NCI-H2110	lung	COSMIC	DSGEGPS	DEG_SCF_TRCP1_1	0.7532
p.E417G	DO35654	PBCA	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.6087
p.G421E	TCGA-GN-A263	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	0.3056
p.G421E	DO37766	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.3056
p.M422V	SIDM00068	Colorectal Carcinoma	GDSC	DSGEGPS	DEG_SCF_TRCP1_1	0.2778
p.M422V	ACH-002394	Colon/Colorectal Cancer	CCLE	DSGEGPS	DEG_SCF_TRCP1_1	0.2778
p.A411V	MDA-MB-361	breast	COSMIC	DSGEGPS	DEG_SCF_TRCP1_1	0.25
p.E410D	TCGA-AP-A1DV	UCEC	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	0.2222
p.E410D	DO43186	UCEC	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.2222
p.D407V	TCGA-FS-A1Z3	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	0.1389
p.D407V	DO37635	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.1389
p.C427Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGEGPS	DEG_SCF_TRCP1_1	0.1389
p.C427Y	ACH-000937	Leukemia	CCLE	DSGEGPS	DEG_SCF_TRCP1_1	0.1389
p.C427Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGEGPS	DEG_SCF_TRCP1_1	0.1389
p.H404Y	TCGA-CK-4951	COAD	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	0.0556
p.H404Y	TCGA-GN-A26A	SKCM	TCGA	DSGEGPS	DEG_SCF_TRCP1_1	0.0556
p.H404Y	DO10582	COAD	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.0556
p.H404Y	DO37861	SKCM	ICGC	DSGEGPS	DEG_SCF_TRCP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UER7	Death domain-associated protein 6	DEG_SCF_TRCP1_1	414:420	DSGEGPS	BTRC	0.9984	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons