DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGEGPS
Uniprot ID:
Q9UER7
Source protein:
Death domain-associated protein 6
Source gene:
DAXX
Class:
DEG_SCF_TRCP1_1
Location:
414:420
E3 ligase:
BTRC
DEGRON score:
0.9984
ASA_SCORE:
82.0571
COIL:
0.9161
CONS_SCORE:
0.3785
DSS_SCORE:
0.8211
HELIX:
0.066
FCONS_SCORE:
1.0611
RIG_SCORE:
0.5002
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E410D
TCGA-AP-A1DV
UCEC
TCGA
DSGEGPS
DEG_SCF_TRCP1_1
0.2222
p.E410D
DO43186
UCEC
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.2222
p.S415F
TCGA-BP-4987
KIRC
TCGA
DSGEGPS
DEG_SCF_TRCP1_1
0.9093
p.S415F
DO19088
KIRC
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.9093
p.H404Y
TCGA-CK-4951
COAD
TCGA
DSGEGPS
DEG_SCF_TRCP1_1
0.0556
p.H404Y
TCGA-GN-A26A
SKCM
TCGA
DSGEGPS
DEG_SCF_TRCP1_1
0.0556
p.H404Y
DO10582
COAD
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.0556
p.H404Y
DO37861
SKCM
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.0556
p.G416C
TCGA-D3-A2JP
SKCM
TCGA
DSGEGPS
DEG_SCF_TRCP1_1
0.76
p.G416C
DO47407
SKCM
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.76
p.D407V
TCGA-FS-A1Z3
SKCM
TCGA
DSGEGPS
DEG_SCF_TRCP1_1
0.1389
p.D407V
DO37635
SKCM
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.1389
p.G421E
TCGA-GN-A263
SKCM
TCGA
DSGEGPS
DEG_SCF_TRCP1_1
0.3056
p.G421E
DO37766
SKCM
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.3056
p.E417G
DO35654
PBCA
ICGC
DSGEGPS
DEG_SCF_TRCP1_1
0.6087
p.G416V
SIDM00703
Non-Small Cell Lung Carcinoma
GDSC
DSGEGPS
DEG_SCF_TRCP1_1
0.7532
p.G416V
ACH-000929
Lung Cancer
CCLE
DSGEGPS
DEG_SCF_TRCP1_1
0.7532
p.G416V
NCI-H2110
lung
COSMIC
DSGEGPS
DEG_SCF_TRCP1_1
0.7532
p.M422V
SIDM00068
Colorectal Carcinoma
GDSC
DSGEGPS
DEG_SCF_TRCP1_1
0.2778
p.M422V
ACH-002394
Colon/Colorectal Cancer
CCLE
DSGEGPS
DEG_SCF_TRCP1_1
0.2778
p.C427Y
SIDM00451
T-Lymphoblastic Leukemia
GDSC
DSGEGPS
DEG_SCF_TRCP1_1
0.1389
p.C427Y
ACH-000937
Leukemia
CCLE
DSGEGPS
DEG_SCF_TRCP1_1
0.1389
p.C427Y
PF-382
haematopoietic_and_lymphoid_tissue
COSMIC
DSGEGPS
DEG_SCF_TRCP1_1
0.1389
p.A411V
MDA-MB-361
breast
COSMIC
DSGEGPS
DEG_SCF_TRCP1_1
0.25
Drug responses associated with DAXX mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGEGPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UER7
Death domain-associated protein 6
DEG_SCF_TRCP1_1
414:420
DSGEGPS
BTRC
0.9984
More...