DegronMD

Uniprot ID: Q9UER7

Source protein: Death domain-associated protein 6

Source gene: DAXX

Class: DEG_Kelch_Keap1_1

Location: 412:417

E3 ligase: KEAP1

DEGRON score: 0.9463

ASA_SCORE: 84.5833

COIL: 0.8923

CONS_SCORE: 0.3454

DSS_SCORE: 0.8163

HELIX: 0.0915

FCONS_SCORE: 0.9944

RIG_SCORE: 0.5323

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S402F	TCGA-98-A538	LUSC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.5
p.S402F	DO219177	LUSC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.5
p.L413F	TCGA-A3-A8OU	KIRC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.587
p.L413F	DO219231	KIRC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.587
p.E410D	TCGA-AP-A1DV	UCEC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.2778
p.E410D	DO43186	UCEC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.2778
p.S415F	TCGA-BP-4987	KIRC	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.9093
p.S415F	DO19088	KIRC	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.9093
p.H404Y	TCGA-CK-4951	COAD	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.1111
p.H404Y	TCGA-GN-A26A	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.1111
p.H404Y	DO10582	COAD	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.1111
p.H404Y	DO37861	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.1111
p.G416C	TCGA-D3-A2JP	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.76
p.G416C	DO47407	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.76
p.D407V	TCGA-FS-A1Z3	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.1944
p.D407V	DO37635	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.1944
p.G421E	TCGA-GN-A263	SKCM	TCGA	SLDSGE	DEG_Kelch_Keap1_1	0.2222
p.G421E	DO37766	SKCM	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.2222
p.E417G	DO35654	PBCA	ICGC	SLDSGE	DEG_Kelch_Keap1_1	0.7199
p.G416V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SLDSGE	DEG_Kelch_Keap1_1	0.7532
p.G416V	ACH-000929	Lung Cancer	CCLE	SLDSGE	DEG_Kelch_Keap1_1	0.7532
p.G416V	NCI-H2110	lung	COSMIC	SLDSGE	DEG_Kelch_Keap1_1	0.7532
p.M422V	SIDM00068	Colorectal Carcinoma	GDSC	SLDSGE	DEG_Kelch_Keap1_1	0.1944
p.M422V	ACH-002394	Colon/Colorectal Cancer	CCLE	SLDSGE	DEG_Kelch_Keap1_1	0.1944
p.C427Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	SLDSGE	DEG_Kelch_Keap1_1	0.0556
p.C427Y	ACH-000937	Leukemia	CCLE	SLDSGE	DEG_Kelch_Keap1_1	0.0556
p.C427Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	SLDSGE	DEG_Kelch_Keap1_1	0.0556
p.A411V	MDA-MB-361	breast	COSMIC	SLDSGE	DEG_Kelch_Keap1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SLDSGE

Degron related mutations and impact score

Drug responses associated with DAXX mutations

All proteins holding degron of SLDSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UER7	Death domain-associated protein 6	DEG_Kelch_Keap1_1	412:417	SLDSGE	KEAP1	0.9463	More...