DegronMD

Uniprot ID: Q9UER7

Source protein: Death domain-associated protein 6

Source gene: DAXX

Class: DEG_Kelch_Keap1_1

Location: 515:520

E3 ligase: KEAP1

DEGRON score: 0.9831

ASA_SCORE: 84.0667

COIL: 0.7847

CONS_SCORE: 0.4053

DSS_SCORE: 0.7203

HELIX: 0.17

FCONS_SCORE: 1.0016

RIG_SCORE: 0.5899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K512E	TCGA-AJ-A3EK	UCEC	TCGA	SRSSGE	DEG_Kelch_Keap1_1	0.6944
p.K512E	DO41584	UCEC	ICGC	SRSSGE	DEG_Kelch_Keap1_1	0.6944
p.R526H	TCGA-BR-4184	STAD	TCGA	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.R526H	TCGA-EA-A3HU	CESC	TCGA	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.R526H	DO6320	CESC	ICGC	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.R526H	DO233864	GACA	ICGC	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.R526H	DO38328	STAD	ICGC	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.I527V	TCGA-BR-8680	STAD	TCGA	SRSSGE	DEG_Kelch_Keap1_1	0.1389
p.I527V	DO47769	STAD	ICGC	SRSSGE	DEG_Kelch_Keap1_1	0.1389
p.N523S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRSSGE	DEG_Kelch_Keap1_1	0.25
p.N523S	ACH-000981	Leukemia	CCLE	SRSSGE	DEG_Kelch_Keap1_1	0.25
p.N523S	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	SRSSGE	DEG_Kelch_Keap1_1	0.25
p.R526C	SIDM01043	Other Sarcomas	GDSC	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.R526C	ACH-000913	Endometrial/Uterine Cancer	CCLE	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.R526C	ESS-1	endometrium	COSMIC	SRSSGE	DEG_Kelch_Keap1_1	0.1667
p.S515N	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SRSSGE	DEG_Kelch_Keap1_1	0.7069
p.S515N	ACH-000925	Lung Cancer	CCLE	SRSSGE	DEG_Kelch_Keap1_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UER7	Death domain-associated protein 6	DEG_Kelch_Keap1_1	515:520	SRSSGE	KEAP1	0.9831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons