DegronMD

Uniprot ID: Q9UER7

Source protein: Death domain-associated protein 6

Source gene: DAXX

Class: DEG_SPOP_SBC_1

Location: 680:684

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 77.58

COIL: 0.9128

CONS_SCORE: 0.3226

DSS_SCORE: 0.5291

HELIX: 0.0496

FCONS_SCORE: 0.9801

RIG_SCORE: 0.644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P670H	TCGA-13-1484	OV	TCGA	ADSST	DEG_SPOP_SBC_1	0.0556
p.P670H	DO29006	OV	ICGC	ADSST	DEG_SPOP_SBC_1	0.0556
p.S682C	TCGA-B0-5115	KIRC	TCGA	ADSST	DEG_SPOP_SBC_1	0.7541
p.S682C	DO18761	KIRC	ICGC	ADSST	DEG_SPOP_SBC_1	0.7541
p.S671F	TCGA-CN-A6V1	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	0.5278
p.S671F	DO52048	HNSC	ICGC	ADSST	DEG_SPOP_SBC_1	0.5278
p.R685M	TCGA-DU-6392	LGG	TCGA	ADSST	DEG_SPOP_SBC_1	0.3056
p.R685M	DO22237	LGG	ICGC	ADSST	DEG_SPOP_SBC_1	0.3056
p.T684M	DO225313	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.7423
p.P678L	DO222731	MELA	ICGC	ADSST	DEG_SPOP_SBC_1	0.2778
p.S671P	DO229232	THCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.5278
p.S671P	SIDM01045	Endometrial Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.5278
p.S671P	ACH-000978	Endometrial/Uterine Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.5278
p.S671P	EN	endometrium	COSMIC	ADSST	DEG_SPOP_SBC_1	0.5278
p.D687V	SIDM01314	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.25
p.S683Y	ACH-000887	Brain Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.8231
p.C673Y	U-CH2	bone	COSMIC	ADSST	DEG_SPOP_SBC_1	0.1389
p.H683Y	MFE-319	endometrium	COSMIC	ADSST	DEG_SPOP_SBC_1	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	1689:1693	ADSST	SPOP	0.9922	More...
P35659	Protein DEK	DEG_SPOP_SBC_1	285:289	ADSST	SPOP	0.9954	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1481:1485	ADSST	SPOP	0.9987	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	774:778	ADSST	SPOP	0.9891	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	1169:1173	ADSST	SPOP	0.9539	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	398:402	ADSST	SPOP	0.8996	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	680:684	ADSST	SPOP	0.9989	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	335:339	ADSST	SPOP	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons