DegronMD - Q14005(IL16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A636V	TCGA-19-5956	GBM	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation altering degron motif	0.5825
p.A636V	DO13863	GBM	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation altering degron motif	0.5825
p.P783T	TCGA-44-2655	LUAD	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.0833
p.P783T	TCGA-44-2655	LUAD	TCGA	ADSST	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1944
p.P783H	TCGA-44-2655	LUAD	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.0833
p.P783H	TCGA-44-2655	LUAD	TCGA	ADSST	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1944
p.D762N	TCGA-55-1592	LUAD	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.2778
p.P783A	TCGA-61-2095	OV	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.0833
p.P783A	TCGA-61-2095	OV	TCGA	ADSST	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1944
p.F1246L	TCGA-77-7465	LUSC	TCGA	KGSLHGD	LIG_APCC_ABBAyCdc20_2	1252:1258	Mutation rewiring degron network	0.1667
p.R793C	TCGA-AA-3984	COAD	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8301
p.R793C	TCGA-D1-A16X	UCEC	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8301
p.R793C	TCGA-GN-A26C	SKCM	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8301
p.R793C	SIDM00944	Colorectal Carcinoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8301
p.R793C	ACH-000249	Colon/Colorectal Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8301
p.R793C	CL-11	large intestine	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8301
p.R652I	TCGA-AG-A002	READ	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1111
p.T750I	TCGA-AP-A051	UCEC	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.25
p.R842I	TCGA-AX-A0J0	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.1667
p.R842I	TCGA-MP-A4T4	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.1667
p.W791L	TCGA-BF-A1PZ	SKCM	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.3056
p.G749E	TCGA-CJ-4923	KIRC	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.2222
p.T628A	TCGA-CM-6161	COAD	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1111
p.T628A	DO10116	COAD	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1111
p.A764T	TCGA-CQ-5332	HNSC	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.2222
p.A764T	TCGA-CQ-5332	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0556
p.A764T	SIDM02015	Colorectal Carcinoma	GDSC	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.2222
p.A764T	SIDM02015	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0556
p.E647K	TCGA-DD-A1EE	LIHC	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.25
p.E647K	TCGA-G3-A25U	LIHC	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.25
p.E647K	DO22857	LIHC	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.25
p.E647K	DO22863	LIHC	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.25
p.E647K	DO52686	MALY	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.25
p.T649R	TCGA-DF-A2KU	UCEC	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1944
p.T649R	DO223286	UCEC	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1944
p.P784S	TCGA-EE-A181	SKCM	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1111
p.P784S	TCGA-EE-A181	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1667
p.Q646H	TCGA-EE-A183	SKCM	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.2778
p.A786T	TCGA-EL-A3CM	THCA	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1667
p.A786T	TCGA-EL-A3CM	THCA	TCGA	ADSST	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1111
p.P758S	TCGA-ER-A19D	SKCM	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation altering degron motif	0.6752
p.G1245D	TCGA-EY-A1G8	UCEC	TCGA	KGSLHGD	LIG_APCC_ABBAyCdc20_2	1252:1258	Mutation rewiring degron network	0.1389
p.R823M	TCGA-FS-A1ZQ	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.0833
p.P630T	TCGA-HU-8602	STAD	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1667
p.P630T	DO47829	STAD	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1667
p.D1258N	TCGA-XQ-A8TA	PRAD	TCGA	KGSLHGD	LIG_APCC_ABBAyCdc20_2	1252:1258	Mutation altering degron motif	0.6932
p.L644P	DO229264	THCA	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation altering degron motif	0.6471
p.S804L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation blocking phosphorylation signal	0.6667
p.S804L	ACH-000920	Leukemia	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation blocking phosphorylation signal	0.6667
p.S804L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation blocking phosphorylation signal	0.6667
p.R793H	SIDM01043	Other Sarcomas	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8244
p.R793H	ACH-000913	Endometrial/Uterine Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8244
p.R793H	ESS-1	endometrium	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.8244
p.D775G	SIDM00846	Cervical Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.6087
p.P629L	SIDM00282	Colorectal Carcinoma	GDSC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.P629L	ACH-000998	Colon/Colorectal Cancer	CCLE	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.P629L	CW-2	large intestine	COSMIC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.E748K	SIDM00995	Other Solid Cancers	GDSC	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.1944
p.E748K	ACH-001328	Skin Cancer	CCLE	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.1944
p.E748K	A431	skin	COSMIC	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation rewiring degron network	0.1944
p.R802S	SIDM00930	Osteosarcoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2778
p.R802S	CAL-72	bone	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2778
p.N801D	SIDM00534	Colorectal Carcinoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.3056
p.N801D	ACH-000986	Colon/Colorectal Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.3056
p.N801D	HT-115	large intestine	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.3056
p.A650V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1667
p.A650V	ACH-001737	Leukemia	CCLE	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1667
p.A650V	ACH-002222	Leukemia	CCLE	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1667
p.A650V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARELLPLLL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1667
p.R802H	SIDM00485	Oral Cavity Carcinoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2778
p.R802H	ACH-000794	Head and Neck Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2778
p.R802H	BICR22	upper aerodigestive tract	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2778
p.I1266M	SIDM00150	Colorectal Carcinoma	GDSC	KGSLHGD	LIG_APCC_ABBAyCdc20_2	1252:1258	Mutation rewiring degron network	0.1111
p.I1266M	KM12	large intestine	COSMIC	KGSLHGD	LIG_APCC_ABBAyCdc20_2	1252:1258	Mutation rewiring degron network	0.1111
p.R831W	ACH-000095	Brain Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	832:836	Mutation rewiring degron network	0.3056
p.I1265M	ACH-000969	Colon/Colorectal Cancer	CCLE	KGSLHGD	LIG_APCC_ABBAyCdc20_2	1252:1258	Mutation rewiring degron network	0.1389
p.I1265M	KM12	large intestine	COSMIC	KGSLHGD	LIG_APCC_ABBAyCdc20_2	1252:1258	Mutation rewiring degron network	0.1389
p.D755N	ACH-001982	Metastasis	CCLE	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	753:760	Mutation altering degron motif	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL16

UniProt ID: Q14005

Entrez ID: 3603

Protein name: Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL16 in