DegronMD

Uniprot ID: Q14005

Source protein: Pro-interleukin-16 [Cleaved into: Interleukin-16

Source gene: IL16

Class: LIG_APCC_ABBAyCdc20_2

Location: 1252:1258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 65.3

COIL: 0.8879

CONS_SCORE: 0.5636

DSS_SCORE: 0.3638

HELIX: 0.0453

FCONS_SCORE: 0.8729

RIG_SCORE: 0.6556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1246L	TCGA-77-7465	LUSC	TCGA	KGSLHGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G1245D	TCGA-EY-A1G8	UCEC	TCGA	KGSLHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D1258N	TCGA-XQ-A8TA	PRAD	TCGA	KGSLHGD	LIG_APCC_ABBAyCdc20_2	0.6932
p.I1266M	SIDM00150	Colorectal Carcinoma	GDSC	KGSLHGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.I1266M	KM12	large_intestine	COSMIC	KGSLHGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.I1265M	ACH-000969	Colon/Colorectal Cancer	CCLE	KGSLHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.I1265M	KM12	large_intestine	COSMIC	KGSLHGD	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	LIG_APCC_ABBAyCdc20_2	1252:1258	KGSLHGD	APC,CDC20,FZR1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons