DegronMD

Uniprot ID: Q14005

Source protein: Pro-interleukin-16 [Cleaved into: Interleukin-16

Source gene: IL16

Class: DEG_SCF_SKP2-CKS1_1

Location: 753:760

E3 ligase: SKP2,CSK1

DEGRON score: 0.9941

ASA_SCORE: 88.65

COIL: 0.9419

CONS_SCORE: 0.507

DSS_SCORE: 0.8329

HELIX: 0.0274

FCONS_SCORE: 1.166

RIG_SCORE: 0.572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D762N	TCGA-55-1592	LUAD	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.2778
p.T750I	TCGA-AP-A051	UCEC	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.25
p.G749E	TCGA-CJ-4923	KIRC	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A764T	TCGA-CQ-5332	HNSC	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A764T	SIDM02015	Colorectal Carcinoma	GDSC	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P758S	TCGA-ER-A19D	SKCM	TCGA	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.6752
p.E748K	SIDM00995	Other Solid Cancers	GDSC	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E748K	ACH-001328	Skin Cancer	CCLE	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E748K	A431	skin	COSMIC	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D755N	ACH-001982	Metastasis	CCLE	HPDGTPPK	DEG_SCF_SKP2-CKS1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SCF_SKP2-CKS1_1	753:760	HPDGTPPK	SKP2,CSK1	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons