DegronMD

Uniprot ID: Q14005

Source protein: Pro-interleukin-16 [Cleaved into: Interleukin-16

Source gene: IL16

Class: DEG_APCC_DBOX_1

Location: 636:644

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6986

ASA_SCORE: 88.2222

COIL: 0.7207

CONS_SCORE: 0.4769

DSS_SCORE: 0.6764

HELIX: 0.2417

FCONS_SCORE: 0.9806

RIG_SCORE: 0.7833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A636V	TCGA-19-5956	GBM	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.5825
p.A636V	DO13863	GBM	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.5825
p.R652I	TCGA-AG-A002	READ	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.1111
p.T628A	TCGA-CM-6161	COAD	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.1111
p.T628A	DO10116	COAD	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.1111
p.E647K	TCGA-DD-A1EE	LIHC	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.25
p.E647K	TCGA-G3-A25U	LIHC	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.25
p.E647K	DO22857	LIHC	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.25
p.E647K	DO22863	LIHC	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.25
p.E647K	DO52686	MALY	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.25
p.T649R	TCGA-DF-A2KU	UCEC	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.1944
p.T649R	DO223286	UCEC	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.1944
p.Q646H	TCGA-EE-A183	SKCM	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.2778
p.P630T	TCGA-HU-8602	STAD	TCGA	ARELLPLLL	DEG_APCC_DBOX_1	0.1667
p.P630T	DO47829	STAD	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.1667
p.L644P	DO229264	THCA	ICGC	ARELLPLLL	DEG_APCC_DBOX_1	0.6471
p.P629L	SIDM00282	Colorectal Carcinoma	GDSC	ARELLPLLL	DEG_APCC_DBOX_1	0.1389
p.P629L	ACH-000998	Colon/Colorectal Cancer	CCLE	ARELLPLLL	DEG_APCC_DBOX_1	0.1389
p.P629L	CW-2	large_intestine	COSMIC	ARELLPLLL	DEG_APCC_DBOX_1	0.1389
p.A650V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARELLPLLL	DEG_APCC_DBOX_1	0.1667
p.A650V	ACH-001737	Leukemia	CCLE	ARELLPLLL	DEG_APCC_DBOX_1	0.1667
p.A650V	ACH-002222	Leukemia	CCLE	ARELLPLLL	DEG_APCC_DBOX_1	0.1667
p.A650V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARELLPLLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_APCC_DBOX_1	636:644	ARELLPLLL	APC,CDC20,FZR1	0.6986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons