DegronMD

Uniprot ID: Q14005

Source protein: Pro-interleukin-16 [Cleaved into: Interleukin-16

Source gene: IL16

Class: DEG_APCC_DBOX_1

Location: 792:800

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9142

ASA_SCORE: 83.6111

COIL: 0.4517

CONS_SCORE: 0.5862

DSS_SCORE: 0.5873

HELIX: 0.4788

FCONS_SCORE: 1.1568

RIG_SCORE: 0.7356

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P783T	TCGA-44-2655	LUAD	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.0833
p.P783H	TCGA-44-2655	LUAD	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.0833
p.P783A	TCGA-61-2095	OV	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.0833
p.R793C	TCGA-AA-3984	COAD	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.8301
p.R793C	TCGA-D1-A16X	UCEC	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.8301
p.R793C	TCGA-GN-A26C	SKCM	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.8301
p.R793C	SIDM00944	Colorectal Carcinoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	0.8301
p.R793C	ACH-000249	Colon/Colorectal Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	0.8301
p.R793C	CL-11	large_intestine	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	0.8301
p.W791L	TCGA-BF-A1PZ	SKCM	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.3056
p.P784S	TCGA-EE-A181	SKCM	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.1111
p.A786T	TCGA-EL-A3CM	THCA	TCGA	FRQSLKGLR	DEG_APCC_DBOX_1	0.1667
p.S804L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	0.6667
p.S804L	ACH-000920	Leukemia	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	0.6667
p.S804L	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	0.6667
p.R793H	SIDM01043	Other Sarcomas	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	0.8244
p.R793H	ACH-000913	Endometrial/Uterine Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	0.8244
p.R793H	ESS-1	endometrium	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	0.8244
p.R802S	SIDM00930	Osteosarcoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	0.2778
p.R802S	CAL-72	bone	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	0.2778
p.N801D	SIDM00534	Colorectal Carcinoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	0.3056
p.N801D	ACH-000986	Colon/Colorectal Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	0.3056
p.N801D	HT-115	large_intestine	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	0.3056
p.R802H	SIDM00485	Oral Cavity Carcinoma	GDSC	FRQSLKGLR	DEG_APCC_DBOX_1	0.2778
p.R802H	ACH-000794	Head and Neck Cancer	CCLE	FRQSLKGLR	DEG_APCC_DBOX_1	0.2778
p.R802H	BICR22	upper_aerodigestive_tract	COSMIC	FRQSLKGLR	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRQSLKGLR

Degron related mutations and impact score

Drug responses associated with IL16 mutations

All proteins holding degron of FRQSLKGLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_APCC_DBOX_1	792:800	FRQSLKGLR	APC,CDC20,FZR1	0.9142	More...