DegronMD - Q14CM0(FRMPD4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1169T	TCGA-32-2495	GBM	TCGA	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation altering degron motif	0.7139
p.A1169T	DO11908	GBM	ICGC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation altering degron motif	0.7139
p.P901T	TCGA-55-A491	LUAD	TCGA	PESSS	DEG_SPOP_SBC_1	901:905	Mutation altering degron motif	0.7031
p.P901T	DO25787	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	901:905	Mutation altering degron motif	0.7031
p.L701I	TCGA-AP-A059	UCEC	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.6063
p.L701I	DO41361	UCEC	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.6063
p.R897W	TCGA-AP-A1DV	UCEC	TCGA	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.0833
p.R897W	TCGA-AP-A1DV	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2222
p.R897W	TCGA-BR-8588	STAD	TCGA	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.0833
p.R897W	TCGA-BR-8588	STAD	TCGA	PESSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2222
p.R897W	DO47855	STAD	ICGC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.0833
p.R897W	DO47855	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2222
p.R897W	DO43186	UCEC	ICGC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.0833
p.R897W	DO43186	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.2222
p.K1179R	TCGA-CC-A9FW	LIHC	TCGA	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation substituting flanking lysine	0.2778
p.K1179R	DO219557	LIHC	ICGC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation substituting flanking lysine	0.2778
p.M916I	TCGA-D3-A8GI	SKCM	TCGA	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1944
p.M916I	DO50284	SKCM	ICGC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1944
p.E712K	TCGA-DU-6392	LGG	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation rewiring degron network	0.1667
p.E712K	DO22237	LGG	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation rewiring degron network	0.1667
p.S903C	TCGA-EA-A43B	CESC	TCGA	PESSS	DEG_SPOP_SBC_1	901:905	Mutation altering degron motif	0.7541
p.S903C	DO44384	CESC	ICGC	PESSS	DEG_SPOP_SBC_1	901:905	Mutation altering degron motif	0.7541
p.L699M	TCGA-EY-A215	UCEC	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.5999
p.L699M	DO42665	UCEC	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.5999
p.L701R	TCGA-FI-A2D5	UCEC	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.7316
p.L701R	DO41331	UCEC	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.7316
p.E918G	TCGA-HU-A4H8	STAD	TCGA	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1389
p.E918G	DO47869	STAD	ICGC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1389
p.P703Q	TCGA-L9-A444	LUAD	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.7035
p.P703Q	DO26015	LUAD	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.7035
p.E918Q	TCGA-MA-AA3Z	CESC	TCGA	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1389
p.E918Q	TCGA-MV-A51V	BLCA	TCGA	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1389
p.E918Q	DO474	BLCA	ICGC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1389
p.E918Q	DO219722	CESC	ICGC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1389
p.E918K	TCGA-N9-A4Q7	UCS	TCGA	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.1389
p.S904L	TCGA-YD-A9TA	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	901:905	Mutation altering degron motif	0.8778
p.S904L	DO219503	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	901:905	Mutation altering degron motif	0.8778
p.S1159L	DO225215	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation rewiring degron network	0.0556
p.S1159L	DO227836	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation rewiring degron network	0.0556
p.S900T	DO225396	BRCA	ICGC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation blocking phosphorylation signal	0.6111
p.S900T	DO225396	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	901:905	Mutation blocking phosphorylation signal	0.75
p.S1172F	DO220906	MELA	ICGC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation altering degron motif	0.7982
p.ED1167EN	DO222843	MELA	ICGC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation rewiring degron network	0
p.A894V	DO230449	UTCA	ICGC	PESSS	DEG_SPOP_SBC_1	901:905	Mutation rewiring degron network	0.1389
p.E910G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation altering degron motif	0.6087
p.E910G	ACH-000983	Leukemia	CCLE	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation altering degron motif	0.6087
p.E910G	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation altering degron motif	0.6087
p.D1162E	SIDM00414	Bladder Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation rewiring degron network	0.1389
p.D1162E	ACH-000545	Bladder Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation rewiring degron network	0.1389
p.D1162E	VM-CUB-1	urinary tract	COSMIC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation rewiring degron network	0.1389
p.A1169S	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation altering degron motif	0.7588
p.A1169S	ACH-000869	Lung Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation altering degron motif	0.7588
p.A1169S	NCI-H1568	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation altering degron motif	0.7588
p.G691V	SIDM01724	Melanoma	GDSC	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation rewiring degron network	0.1111
p.E704V	ACH-001366	Neuroblastoma	CCLE	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation altering degron motif	0.6582
p.S920F	ACH-001610	Brain Cancer	CCLE	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.0833
p.D1170E	ACH-002046	Endometrial/Uterine Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation altering degron motif	0.5647
p.S1164N	OC-314	ovary	COSMIC	ADSST	DEG_SPOP_SBC_1	1169:1173	Mutation rewiring degron network	0.1944
p.D707N	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LDLTPEAE	DEG_SCF_FBW7_2	699:706	Mutation rewiring degron network	0.3056
p.A920V	HEC-1	endometrium	COSMIC	DSGNET	DEG_SCF_TRCP1_1	906:911	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMPD4

UniProt ID: Q14CM0

Entrez ID: 9758

Protein name: FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRMPD4 in