DegronMD

Uniprot ID: Q14CM0

Source protein: FERM and PDZ domain-containing protein 4

Source gene: FRMPD4

Class: DEG_SCF_TRCP1_1

Location: 906:911

E3 ligase: BTRC

DEGRON score: 0.7494

ASA_SCORE: 76.9

COIL: 0.8182

CONS_SCORE: 0.4195

DSS_SCORE: 0.7425

HELIX: 0.1413

FCONS_SCORE: 0.9535

RIG_SCORE: 0.5027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R897W	TCGA-AP-A1DV	UCEC	TCGA	DSGNET	DEG_SCF_TRCP1_1	0.0833
p.R897W	TCGA-BR-8588	STAD	TCGA	DSGNET	DEG_SCF_TRCP1_1	0.0833
p.R897W	DO47855	STAD	ICGC	DSGNET	DEG_SCF_TRCP1_1	0.0833
p.R897W	DO43186	UCEC	ICGC	DSGNET	DEG_SCF_TRCP1_1	0.0833
p.M916I	TCGA-D3-A8GI	SKCM	TCGA	DSGNET	DEG_SCF_TRCP1_1	0.1944
p.M916I	DO50284	SKCM	ICGC	DSGNET	DEG_SCF_TRCP1_1	0.1944
p.E918G	TCGA-HU-A4H8	STAD	TCGA	DSGNET	DEG_SCF_TRCP1_1	0.1389
p.E918G	DO47869	STAD	ICGC	DSGNET	DEG_SCF_TRCP1_1	0.1389
p.E918Q	TCGA-MA-AA3Z	CESC	TCGA	DSGNET	DEG_SCF_TRCP1_1	0.1389
p.E918Q	TCGA-MV-A51V	BLCA	TCGA	DSGNET	DEG_SCF_TRCP1_1	0.1389
p.E918Q	DO474	BLCA	ICGC	DSGNET	DEG_SCF_TRCP1_1	0.1389
p.E918Q	DO219722	CESC	ICGC	DSGNET	DEG_SCF_TRCP1_1	0.1389
p.E918K	TCGA-N9-A4Q7	UCS	TCGA	DSGNET	DEG_SCF_TRCP1_1	0.1389
p.S900T	DO225396	BRCA	ICGC	DSGNET	DEG_SCF_TRCP1_1	0.6111
p.E910G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGNET	DEG_SCF_TRCP1_1	0.6087
p.E910G	ACH-000983	Leukemia	CCLE	DSGNET	DEG_SCF_TRCP1_1	0.6087
p.E910G	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNET	DEG_SCF_TRCP1_1	0.6087
p.S920F	ACH-001610	Brain Cancer	CCLE	DSGNET	DEG_SCF_TRCP1_1	0.0833
p.A920V	HEC-1	endometrium	COSMIC	DSGNET	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SCF_TRCP1_1	906:911	DSGNET	BTRC	0.7494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons