DegronMD

Uniprot ID: Q14CM0

Source protein: FERM and PDZ domain-containing protein 4

Source gene: FRMPD4

Class: DEG_SCF_FBW7_2

Location: 699:706

E3 ligase: FBXW7

DEGRON score: 0.9827

ASA_SCORE: 80.925

COIL: 0.767

CONS_SCORE: 0.4107

DSS_SCORE: 0.3452

HELIX: 0.0988

FCONS_SCORE: 0.9693

RIG_SCORE: 0.7863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L701I	TCGA-AP-A059	UCEC	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	0.6063
p.L701I	DO41361	UCEC	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	0.6063
p.E712K	TCGA-DU-6392	LGG	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	0.1667
p.E712K	DO22237	LGG	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	0.1667
p.L699M	TCGA-EY-A215	UCEC	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	0.5999
p.L699M	DO42665	UCEC	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	0.5999
p.L701R	TCGA-FI-A2D5	UCEC	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	0.7316
p.L701R	DO41331	UCEC	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	0.7316
p.P703Q	TCGA-L9-A444	LUAD	TCGA	LDLTPEAE	DEG_SCF_FBW7_2	0.7035
p.P703Q	DO26015	LUAD	ICGC	LDLTPEAE	DEG_SCF_FBW7_2	0.7035
p.G691V	SIDM01724	Melanoma	GDSC	LDLTPEAE	DEG_SCF_FBW7_2	0.1111
p.E704V	ACH-001366	Neuroblastoma	CCLE	LDLTPEAE	DEG_SCF_FBW7_2	0.6582
p.D707N	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LDLTPEAE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SCF_FBW7_2	699:706	LDLTPEAE	FBXW7	0.9827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons