DegronMD

Uniprot ID: Q14CM0

Source protein: FERM and PDZ domain-containing protein 4

Source gene: FRMPD4

Class: DEG_SPOP_SBC_1

Location: 1169:1173

E3 ligase: SPOP

DEGRON score: 0.9539

ASA_SCORE: 80.88

COIL: 0.8606

CONS_SCORE: 0.382

DSS_SCORE: 0.6047

HELIX: 0.1232

FCONS_SCORE: 0.9642

RIG_SCORE: 0.6297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1169T	TCGA-32-2495	GBM	TCGA	ADSST	DEG_SPOP_SBC_1	0.7139
p.A1169T	DO11908	GBM	ICGC	ADSST	DEG_SPOP_SBC_1	0.7139
p.K1179R	TCGA-CC-A9FW	LIHC	TCGA	ADSST	DEG_SPOP_SBC_1	0.2778
p.K1179R	DO219557	LIHC	ICGC	ADSST	DEG_SPOP_SBC_1	0.2778
p.S1159L	DO225215	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.0556
p.S1159L	DO227836	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.0556
p.S1172F	DO220906	MELA	ICGC	ADSST	DEG_SPOP_SBC_1	0.7982
p.ED1167EN	DO222843	MELA	ICGC	ADSST	DEG_SPOP_SBC_1	0
p.D1162E	SIDM00414	Bladder Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.1389
p.D1162E	ACH-000545	Bladder Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.1389
p.D1162E	VM-CUB-1	urinary_tract	COSMIC	ADSST	DEG_SPOP_SBC_1	0.1389
p.A1169S	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.7588
p.A1169S	ACH-000869	Lung Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.7588
p.A1169S	NCI-H1568	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	0.7588
p.D1170E	ACH-002046	Endometrial/Uterine Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.5647
p.S1164N	OC-314	ovary	COSMIC	ADSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	1689:1693	ADSST	SPOP	0.9922	More...
P35659	Protein DEK	DEG_SPOP_SBC_1	285:289	ADSST	SPOP	0.9954	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1481:1485	ADSST	SPOP	0.9987	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	774:778	ADSST	SPOP	0.9891	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	1169:1173	ADSST	SPOP	0.9539	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	398:402	ADSST	SPOP	0.8996	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	680:684	ADSST	SPOP	0.9989	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	335:339	ADSST	SPOP	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons