DegronMD

Uniprot ID: P35659

Source protein: Protein DEK

Source gene: DEK

Class: DEG_SPOP_SBC_1

Location: 285:289

E3 ligase: SPOP

DEGRON score: 0.9954

ASA_SCORE: 93.82

COIL: 0.9202

CONS_SCORE: 0.4938

DSS_SCORE: 0.6591

HELIX: 0.065

FCONS_SCORE: 1.0931

RIG_SCORE: 0.6091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S288T	TCGA-A5-A0GA	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	0.7116
p.S288T	TCGA-HF-A5NB	STAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.7116
p.S288T	TCGA-HU-A4GX	STAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.7116
p.S288T	DO50127	STAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.7116
p.S288T	DO47757	STAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.7116
p.S288T	DO43763	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	0.7116
p.K299I	TCGA-D1-A1NW	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	0.1667
p.K299I	DO41175	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.T289A	TCGA-EB-A3XF	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	0.825
p.T289A	DO37437	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	0.825
p.S288G	SIDM00537	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.8104
p.S288G	ACH-000982	Colon/Colorectal Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.8104
p.S288G	ACH-001345	Colon/Colorectal Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.8104
p.S288G	GP5d	large_intestine	COSMIC	ADSST	DEG_SPOP_SBC_1	0.8104
p.K283R	NCI-H661	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	1689:1693	ADSST	SPOP	0.9922	More...
P35659	Protein DEK	DEG_SPOP_SBC_1	285:289	ADSST	SPOP	0.9954	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1481:1485	ADSST	SPOP	0.9987	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	774:778	ADSST	SPOP	0.9891	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	1169:1173	ADSST	SPOP	0.9539	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	398:402	ADSST	SPOP	0.8996	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	680:684	ADSST	SPOP	0.9989	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	335:339	ADSST	SPOP	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons