DegronMD - P35659(DEK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S288T	TCGA-A5-A0GA	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7116
p.S288T	TCGA-HF-A5NB	STAD	TCGA	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7116
p.S288T	TCGA-HU-A4GX	STAD	TCGA	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7116
p.S288T	DO50127	STAD	ICGC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7116
p.S288T	DO47757	STAD	ICGC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7116
p.S288T	DO43763	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7116
p.K299I	TCGA-D1-A1NW	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	285:289	Mutation substituting flanking lysine	0.1667
p.K299I	DO41175	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation substituting flanking lysine	0.1667
p.T289A	TCGA-EB-A3XF	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.825
p.T289A	DO37437	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.825
p.S288G	SIDM00537	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.8104
p.S288G	ACH-000982	Colon/Colorectal Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.8104
p.S288G	ACH-001345	Colon/Colorectal Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.8104
p.S288G	GP5d	large intestine	COSMIC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.8104
p.K283R	NCI-H661	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons