DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SPOP_SBC_1

Location: 1689:1693

E3 ligase: SPOP

DEGRON score: 0.9922

ASA_SCORE: 98.92

COIL: 0.9466

CONS_SCORE: 0.5354

DSS_SCORE: 0.8664

HELIX: 0.0402

FCONS_SCORE: 1.011

RIG_SCORE: 0.521

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1699H	TCGA-14-0817	GBM	TCGA	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	TCGA-V5-A7RE	ESCA	TCGA	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	DO234459	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	DO13653	GBM	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	SIDM00136	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	SIDM01121	Small Cell Lung Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	ACH-000358	Lung Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	ACH-000552	Colon/Colorectal Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	HT-29	large_intestine	COSMIC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699H	NCI-H69	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	0.1667
p.S1683F	TCGA-18-3415	LUSC	TCGA	ADSST	DEG_SPOP_SBC_1	0.1667
p.S1683F	DO26427	LUSC	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.A1689V	TCGA-55-8507	LUAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.5825
p.A1689V	DO45412	LUAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.5825
p.H1681Y	TCGA-AR-A1AJ	BRCA	TCGA	ADSST	DEG_SPOP_SBC_1	0.1111
p.H1681Y	DO4062	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1111
p.D1690G	TCGA-B5-A0K9	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	0.6087
p.D1690G	DO42097	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	0.6087
p.H1685N	TCGA-BC-A8YO	LIHC	TCGA	ADSST	DEG_SPOP_SBC_1	0.2222
p.H1685N	DO49658	LIHC	ICGC	ADSST	DEG_SPOP_SBC_1	0.2222
p.A1689P	TCGA-CN-6989	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	0.6392
p.A1689P	DO14814	HNSC	ICGC	ADSST	DEG_SPOP_SBC_1	0.6392
p.Q1701K	TCGA-CR-7389	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	0.1111
p.Q1701K	DO14190	HNSC	ICGC	ADSST	DEG_SPOP_SBC_1	0.1111
p.R1700T	TCGA-DM-A1D0	COAD	TCGA	ADSST	DEG_SPOP_SBC_1	0.1389
p.R1700T	DO10260	COAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.1389
p.S1703L	TCGA-QB-A6FS	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	0.5
p.S1703L	DO48654	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	0.5
p.R1684H	DO229010	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1944
p.R1684H	DO229016	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1944
p.R1684H	DO229003	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1944
p.R1684H	DO229489	LAML	ICGC	ADSST	DEG_SPOP_SBC_1	0.1944
p.R1684H	DO228941	LICA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1944
p.R1699C	DO229010	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699C	DO229016	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699C	DO229003	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699C	DO234150	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699C	DO229489	LAML	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1699C	DO228941	LICA	ICGC	ADSST	DEG_SPOP_SBC_1	0.1667
p.R1684C	DO234204	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.1944
p.G1696V	DO234426	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	0.25
p.D1694H	DO231475	THCA	ICGC	ADSST	DEG_SPOP_SBC_1	0.3056
p.Q1701E	SIDM00258	Neuroblastoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.1111
p.Q1701E	NB12	autonomic_ganglia	COSMIC	ADSST	DEG_SPOP_SBC_1	0.1111
p.G1696D	SIDM00350	Head and Neck Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.25
p.G1696D	SAT	upper_aerodigestive_tract	COSMIC	ADSST	DEG_SPOP_SBC_1	0.25
p.Q1686R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	0.25
p.Q1686R	PC-3_[JPC-3]	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	1689:1693	ADSST	SPOP	0.9922	More...
P35659	Protein DEK	DEG_SPOP_SBC_1	285:289	ADSST	SPOP	0.9954	More...
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	1481:1485	ADSST	SPOP	0.9987	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	774:778	ADSST	SPOP	0.9891	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	1169:1173	ADSST	SPOP	0.9539	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	398:402	ADSST	SPOP	0.8996	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	680:684	ADSST	SPOP	0.9989	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	335:339	ADSST	SPOP	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSST

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of ADSST