DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ADSST
Uniprot ID:
Q9H987
Source protein:
Synaptopodin 2-like protein
Source gene:
SYNPO2L
Class:
DEG_SPOP_SBC_1
Location:
398:402
E3 ligase:
SPOP
DEGRON score:
0.8996
ASA_SCORE:
80.8
COIL:
0.4662
CONS_SCORE:
0.4916
DSS_SCORE:
0.6089
HELIX:
0.5288
FCONS_SCORE:
1.0679
RIG_SCORE:
0.6763
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R395C
TCGA-AO-A0JI
BRCA
TCGA
ADSST
DEG_SPOP_SBC_1
0.25
p.R395C
DO2043
BRCA
ICGC
ADSST
DEG_SPOP_SBC_1
0.25
p.R407W
TCGA-AP-A051
UCEC
TCGA
ADSST
DEG_SPOP_SBC_1
0.1944
p.R407W
DO42673
UCEC
ICGC
ADSST
DEG_SPOP_SBC_1
0.1944
p.Q403K
TCGA-EE-A3AD
SKCM
TCGA
ADSST
DEG_SPOP_SBC_1
0.3056
p.Q403K
DO37707
SKCM
ICGC
ADSST
DEG_SPOP_SBC_1
0.3056
p.Q393H
TCGA-IB-7651
PAAD
TCGA
ADSST
DEG_SPOP_SBC_1
0.1944
p.Q393H
DO46657
PAAD
ICGC
ADSST
DEG_SPOP_SBC_1
0.1944
p.A412D
DO229029
LICA
ICGC
ADSST
DEG_SPOP_SBC_1
0.0556
p.V408I
SIDM01007
T-Lymphoblastic Leukemia
GDSC
ADSST
DEG_SPOP_SBC_1
0.1667
p.V408I
ACH-002256
Leukemia
CCLE
ADSST
DEG_SPOP_SBC_1
0.1667
p.V408I
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
ADSST
DEG_SPOP_SBC_1
0.1667
p.M412L
DMS-53
lung
COSMIC
ADSST
DEG_SPOP_SBC_1
0.0556
Drug responses associated with SYNPO2L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ADSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P20930
Filaggrin
DEG_SPOP_SBC_1
1689:1693
ADSST
SPOP
0.9922
More...
P35659
Protein DEK
DEG_SPOP_SBC_1
285:289
ADSST
SPOP
0.9954
More...
P38398
Breast cancer type 1 susceptibility protein
DEG_SPOP_SBC_1
1481:1485
ADSST
SPOP
0.9987
More...
Q14005
Pro-interleukin-16 [Cleaved into: Interleukin-16
DEG_SPOP_SBC_1
774:778
ADSST
SPOP
0.9891
More...
Q14CM0
FERM and PDZ domain-containing protein 4
DEG_SPOP_SBC_1
1169:1173
ADSST
SPOP
0.9539
More...
Q9H987
Synaptopodin 2-like protein
DEG_SPOP_SBC_1
398:402
ADSST
SPOP
0.8996
More...
Q9UER7
Death domain-associated protein 6
DEG_SPOP_SBC_1
680:684
ADSST
SPOP
0.9989
More...
Q12872
Splicing factor, suppressor of white-apricot homolog
DEG_SPOP_SBC_1
335:339
ADSST
SPOP
0.9423
More...