DegronMD - Q8TDJ6(DMXL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L964P	TCGA-23-1124	OV	TCGA	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.2222
p.L964P	DO32596	OV	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.2222
p.S2607F	TCGA-75-6211	LUAD	TCGA	PENTPFKS	DEG_SCF_FBW7_1	2596:2603	Mutation rewiring degron network	0.2222
p.S2607F	TCGA-75-6211	LUAD	TCGA	EPENTPFK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.1944
p.L964I	TCGA-B5-A0JY	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.2222
p.L964I	DO43041	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.2222
p.L2595R	TCGA-BW-A5NQ	LIHC	TCGA	EPENTPFK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation altering degron motif	0.8428
p.R2719C	TCGA-E5-A4U1	BLCA	TCGA	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.3056
p.P950S	TCGA-EE-A29E	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.1667
p.P950S	DO37831	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.1667
p.S958Y	TCGA-EO-A22R	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation altering degron motif	0.712
p.S958Y	DO42713	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation altering degron motif	0.712
p.S949F	TCGA-FW-A3R5	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation blocking phosphorylation signal	0.5833
p.S949F	DO37406	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation blocking phosphorylation signal	0.5833
p.S961C	DO481	BLCA	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.3056
p.V953A	DO8264	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.25
p.P954T	DO229045	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.2778
p.L947Q	DO23344	LINC	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.0833
p.H970Y	DO51273	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation rewiring degron network	0.0556
p.Q2727K	SIDM00418	Thyroid Gland Carcinoma	GDSC	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.0833
p.Q2727K	ACH-000716	Thyroid Cancer	CCLE	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.0833
p.Q2727K	TT2609-C02	thyroid	COSMIC	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.0833
p.P956T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation altering degron motif	0.7031
p.P956T	SIDM01133	Other Solid Cancers	GDSC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation altering degron motif	0.7031
p.P956T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	956:960	Mutation altering degron motif	0.7031
p.T2724S	SIDM00083	Glioblastoma	GDSC	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.1667
p.T2724S	SF539	central nervous system	COSMIC	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.1667
p.E2598K	SIDM00490	Glioma	GDSC	PENTPFKS	DEG_SCF_FBW7_1	2596:2603	Mutation altering degron motif	0.7022
p.E2598K	SIDM00490	Glioma	GDSC	EPENTPFK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation altering degron motif	0.7022
p.E2598K	ACH-001016	Brain Cancer	CCLE	PENTPFKS	DEG_SCF_FBW7_1	2596:2603	Mutation altering degron motif	0.7022
p.E2598K	ACH-001016	Brain Cancer	CCLE	EPENTPFK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation altering degron motif	0.7022
p.E2598K	Becker	central nervous system	COSMIC	PENTPFKS	DEG_SCF_FBW7_1	2596:2603	Mutation altering degron motif	0.7022
p.E2598K	Becker	central nervous system	COSMIC	EPENTPFK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation altering degron motif	0.7022
p.T2724N	ACH-000512	Myeloma	CCLE	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.1667
p.R2590Q	ACH-001786	Colon/Colorectal Cancer	CCLE	PENTPFKS	DEG_SCF_FBW7_1	2596:2603	Mutation rewiring degron network	0.1667
p.R2590Q	ACH-001786	Colon/Colorectal Cancer	CCLE	EPENTPFK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation rewiring degron network	0.1944
p.Q2726K	TT2609-C02	thyroid	COSMIC	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.1111
p.T2723S	SF539	central nervous system	COSMIC	DYR	CBL_MET	2716:2718	Mutation rewiring degron network	0.1944
p.E2597K	Becker	central nervous system	COSMIC	PENTPFKS	DEG_SCF_FBW7_1	2596:2603	Mutation altering degron motif	0.591
p.E2597K	Becker	central nervous system	COSMIC	EPENTPFK	DEG_SCF_SKP2-CKS1_1	2595:2602	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMXL2

UniProt ID: Q8TDJ6

Entrez ID: 23312

Protein name: DmX-like protein 2 (Rabconnectin-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMXL2 in