DegronMD

Uniprot ID: Q8TDJ6

Source protein: DmX-like protein 2

Source gene: DMXL2

Class: DEG_SCF_SKP2-CKS1_1

Location: 2595:2602

E3 ligase: SKP2,CSK1

DEGRON score: 0.9866

ASA_SCORE: 79

COIL: 0.8523

CONS_SCORE: 0.5128

DSS_SCORE: 0.4428

HELIX: 0.0961

FCONS_SCORE: 1.2481

RIG_SCORE: 0.7285

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2595R	TCGA-BW-A5NQ	LIHC	TCGA	EPENTPFK	DEG_SCF_SKP2-CKS1_1	0.8428
p.E2598K	SIDM00490	Glioma	GDSC	EPENTPFK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E2598K	ACH-001016	Brain Cancer	CCLE	EPENTPFK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E2598K	Becker	central_nervous_system	COSMIC	EPENTPFK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E2597K	Becker	central_nervous_system	COSMIC	EPENTPFK	DEG_SCF_SKP2-CKS1_1	0.7022
p.S2607F	TCGA-75-6211	LUAD	TCGA	EPENTPFK	DEG_SCF_SKP2-CKS1_1	0.1944
p.R2590Q	ACH-001786	Colon/Colorectal Cancer	CCLE	EPENTPFK	DEG_SCF_SKP2-CKS1_1	0.1944

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDJ6	DmX-like protein 2	DEG_SCF_SKP2-CKS1_1	2595:2602	EPENTPFK	SKP2,CSK1	0.9866	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons