DegronMD

Uniprot ID: Q8TDJ6

Source protein: DmX-like protein 2

Source gene: DMXL2

Class: DEG_SCF_FBW7_1

Location: 2596:2603

E3 ligase: FBXW7

DEGRON score: 0.745

ASA_SCORE: 72.975

COIL: 0.8385

CONS_SCORE: 0.5023

DSS_SCORE: 0.4345

HELIX: 0.099

FCONS_SCORE: 1.1866

RIG_SCORE: 0.7241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2607F	TCGA-75-6211	LUAD	TCGA	PENTPFKS	DEG_SCF_FBW7_1	0.2222
p.E2598K	SIDM00490	Glioma	GDSC	PENTPFKS	DEG_SCF_FBW7_1	0.7022
p.E2598K	ACH-001016	Brain Cancer	CCLE	PENTPFKS	DEG_SCF_FBW7_1	0.7022
p.E2598K	Becker	central_nervous_system	COSMIC	PENTPFKS	DEG_SCF_FBW7_1	0.7022
p.R2590Q	ACH-001786	Colon/Colorectal Cancer	CCLE	PENTPFKS	DEG_SCF_FBW7_1	0.1667
p.E2597K	Becker	central_nervous_system	COSMIC	PENTPFKS	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDJ6	DmX-like protein 2	DEG_SCF_FBW7_1	2596:2603	PENTPFKS	FBXW7	0.745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons