DegronMD - Q96RT6(CTAGE1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P554T	TCGA-10-0935	OV	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.0556
p.P554T	DO28691	OV	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.0556
p.R669I	TCGA-19-5956	GBM	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.8102
p.R669I	DO13863	GBM	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.8102
p.P567S	TCGA-44-7669	LUAD	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.5641
p.P567S	DO25262	LUAD	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.5641
p.V661F	TCGA-49-AARO	LUAD	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1389
p.V661F	DO218924	LUAD	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1389
p.L672F	TCGA-61-1907	OV	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.6981
p.L672F	DO31260	OV	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.6981
p.P658S	TCGA-85-A4JB	LUSC	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P658S	TCGA-R8-A6MK	LGG	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P658S	DO48735	LGG	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P658S	DO45517	LUSC	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.A561V	TCGA-AA-A01P	COAD	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.25
p.A561V	TCGA-AA-A01P	COAD	TCGA	DYR	CBL_MET	571:573	Mutation rewiring degron network	0.0556
p.A561V	DO8642	COAD	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.25
p.A561V	DO8642	COAD	ICGC	DYR	CBL_MET	571:573	Mutation rewiring degron network	0.0556
p.P674T	TCGA-AN-A046	BRCA	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.5919
p.P674T	DO1285	BRCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation altering degron motif	0.5919
p.A565T	TCGA-B0-5098	KIRC	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.7139
p.A565T	DO18938	KIRC	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.7139
p.G685E	TCGA-CK-4951	COAD	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0833
p.G685E	DO10582	COAD	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0833
p.F576C	TCGA-DK-A6AW	BLCA	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.7108
p.F576C	DO48566	BLCA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.7108
p.P584S	TCGA-EE-A2MU	SKCM	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.1111
p.P584S	DO37436	SKCM	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.1111
p.R556K	TCGA-FR-A726	SKCM	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.1111
p.R556K	DO48665	SKCM	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.1111
p.P662S	TCGA-FW-A3R5	SKCM	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1667
p.P662S	DO37406	SKCM	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1667
p.G685R	TCGA-GC-A3YS	BLCA	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0833
p.G685R	DO850	BLCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0833
p.P662A	TCGA-P3-A5Q5	HNSC	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1667
p.P662A	DO44450	HNSC	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1667
p.I682V	DO229016	COCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1667
p.I682V	DO225404	LAML	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1667
p.Q570K	DO229015	LICA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.5833
p.D571E	DO229045	LICA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.5647
p.D571E	DO229045	LICA	ICGC	DYR	CBL_MET	571:573	Mutation altering degron motif	0.6758
p.Y572H	DO229057	LICA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.6118
p.Y572H	DO229057	LICA	ICGC	DYR	CBL_MET	571:573	Mutation altering degron motif	0.7229
p.Y572H	SIDM00296	Small Cell Lung Carcinoma	GDSC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.6118
p.Y572H	SIDM00296	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	571:573	Mutation altering degron motif	0.7229
p.Y572H	ACH-002051	Lung Cancer	CCLE	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.6118
p.Y572H	ACH-002051	Lung Cancer	CCLE	DYR	CBL_MET	571:573	Mutation altering degron motif	0.7229
p.Y572H	LU-134-A	lung	COSMIC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.6118
p.Y572H	LU-134-A	lung	COSMIC	DYR	CBL_MET	571:573	Mutation altering degron motif	0.7229
p.P566L	DO231018	LUSC	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.7582
p.M574I	DO222868	MELA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation altering degron motif	0.6507
p.G679S	DO218859	SKCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.25
p.I682M	DO229208	THCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1667
p.P667L	SIDM01237	Hepatocellular Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.3056
p.P667L	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.3056
p.P667L	SIDM00882	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.3056
p.P667L	SIDM01749	Osteosarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.3056
p.P667L	SIDM01763	Rhabdomyosarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.3056
p.T677I	SIDM00427	Ewing's Sarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.3056
p.T677I	SIDM00312	Plasma Cell Myeloma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.3056
p.D585N	SIDM01175	Other Sarcomas	GDSC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.0833
p.D585N	SW684	soft tissue	COSMIC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.0833
p.P686T	SIDM00284	Melanoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686T	SIDM00210	Ovarian Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686T	SIDM00529	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686T	SIDM00878	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686T	SIDM00879	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686T	SIDM00844	Burkitt's Lymphoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686T	SIDM00621	Ewing's Sarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.Q581K	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.1944
p.Q581K	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	571:573	Mutation rewiring degron network	0.1111
p.Q581K	NCI-H2023	lung	COSMIC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	564:576	Mutation rewiring degron network	0.1944
p.Q581K	NCI-H2023	lung	COSMIC	DYR	CBL_MET	571:573	Mutation rewiring degron network	0.1111
p.R683K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1389
p.R683K	ACH-001737	Leukemia	CCLE	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1389
p.R683K	ACH-002222	Leukemia	CCLE	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1389
p.R683K	CTV-1	haematopoietic and lymphoid tissue	COSMIC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.1389
p.P686H	SIDM01608	Endometrial Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.P686H	ACH-000990	Endometrial/Uterine Cancer	CCLE	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0556
p.G685A	HSC-39	stomach	COSMIC	IRGLLFPVD	DEG_APCC_DBOX_1	668:676	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTAGE1

UniProt ID: Q96RT6

Entrez ID: 64693

Protein name: cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CTAGE1 in