DegronMD

Uniprot ID: Q96RT6

Source protein: cTAGE family member 2

Source gene: CTAGE1

Class: DEG_APCC_DBOX_1

Location: 668:676

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9869

ASA_SCORE: 72.0333

COIL: 0.9456

CONS_SCORE: 0.586

DSS_SCORE: 0.4391

HELIX: 0.0202

FCONS_SCORE: 0.9515

RIG_SCORE: 0.7682

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R669I	TCGA-19-5956	GBM	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.8102
p.R669I	DO13863	GBM	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.8102
p.V661F	TCGA-49-AARO	LUAD	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.V661F	DO218924	LUAD	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.L672F	TCGA-61-1907	OV	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.6981
p.L672F	DO31260	OV	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.6981
p.P658S	TCGA-85-A4JB	LUSC	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P658S	TCGA-R8-A6MK	LGG	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P658S	DO48735	LGG	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P658S	DO45517	LUSC	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P674T	TCGA-AN-A046	BRCA	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.5919
p.P674T	DO1285	BRCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.5919
p.G685E	TCGA-CK-4951	COAD	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.0833
p.G685E	DO10582	COAD	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0833
p.P662S	TCGA-FW-A3R5	SKCM	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.P662S	DO37406	SKCM	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.G685R	TCGA-GC-A3YS	BLCA	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.0833
p.G685R	DO850	BLCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0833
p.P662A	TCGA-P3-A5Q5	HNSC	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.P662A	DO44450	HNSC	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.I682V	DO229016	COCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.I682V	DO225404	LAML	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.G679S	DO218859	SKCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.25
p.I682M	DO229208	THCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.P667L	SIDM01237	Hepatocellular Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM00882	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM01749	Osteosarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM01763	Rhabdomyosarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.T677I	SIDM00427	Ewing's Sarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.T677I	SIDM00312	Plasma Cell Myeloma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P686T	SIDM00284	Melanoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686T	SIDM00210	Ovarian Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686T	SIDM00529	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686T	SIDM00878	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686T	SIDM00879	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686T	SIDM00844	Burkitt's Lymphoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686T	SIDM00621	Ewing's Sarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.R683K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.R683K	ACH-001737	Leukemia	CCLE	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.R683K	ACH-002222	Leukemia	CCLE	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.R683K	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.P686H	SIDM01608	Endometrial Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.P686H	ACH-000990	Endometrial/Uterine Cancer	CCLE	IRGLLFPVD	DEG_APCC_DBOX_1	0.0556
p.G685A	HSC-39	stomach	COSMIC	IRGLLFPVD	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRGLLFPVD

Degron related mutations and impact score

Drug responses associated with CTAGE1 mutations

All proteins holding degron of IRGLLFPVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RT6	cTAGE family member 2	DEG_APCC_DBOX_1	668:676	IRGLLFPVD	APC,CDC20,FZR1	0.9869	More...