DegronMD

Uniprot ID: Q96RT6

Source protein: cTAGE family member 2

Source gene: CTAGE1

Class: DEG_APCC_DBOX_1

Location: 668:676

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9869

ASA_SCORE: 72.0333

COIL: 0.9456

CONS_SCORE: 0.586

DSS_SCORE: 0.4391

HELIX: 0.0202

FCONS_SCORE: 0.9515

RIG_SCORE: 0.7682

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R669I	TCGA-19-5956	GBM	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.8102
p.R669I	DO13863	GBM	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.8102
p.L672F	TCGA-61-1907	OV	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.6981
p.L672F	DO31260	OV	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.6981
p.P674T	TCGA-AN-A046	BRCA	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.5919
p.P674T	DO1285	BRCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.5919
p.P667L	SIDM01237	Hepatocellular Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM00882	Breast Carcinoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM01749	Osteosarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.P667L	SIDM01763	Rhabdomyosarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.T677I	SIDM00427	Ewing's Sarcoma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.T677I	SIDM00312	Plasma Cell Myeloma	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.3056
p.G679S	DO218859	SKCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.25
p.P662S	TCGA-FW-A3R5	SKCM	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.P662S	DO37406	SKCM	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.P662A	TCGA-P3-A5Q5	HNSC	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.P662A	DO44450	HNSC	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.I682V	DO229016	COCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.I682V	DO225404	LAML	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.I682M	DO229208	THCA	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1667
p.V661F	TCGA-49-AARO	LUAD	TCGA	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.V661F	DO218924	LUAD	ICGC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.R683K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389
p.R683K	ACH-001737	Leukemia	CCLE	IRGLLFPVD	DEG_APCC_DBOX_1	0.1389

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Drug responses associated with CTAGE1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of IRGLLFPVD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RT6	cTAGE family member 2	DEG_APCC_DBOX_1	668:676	IRGLLFPVD	APC,CDC20,FZR1	0.9869	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRGLLFPVD

Degron related mutations and impact score

Drug responses associated with CTAGE1 mutations

All proteins holding degron of IRGLLFPVD