DegronMD

Uniprot ID: Q96RT6

Source protein: cTAGE family member 2

Source gene: CTAGE1

Class: DEG_ODPH_VHL_1

Location: 564:576

E3 ligase: VHL

DEGRON score: 0.9985

ASA_SCORE: 77.2615

COIL: 0.8572

CONS_SCORE: 0.6773

DSS_SCORE: 0.6209

HELIX: 0.1028

FCONS_SCORE: 1.1936

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P554T	TCGA-10-0935	OV	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.0556
p.P554T	DO28691	OV	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.0556
p.P567S	TCGA-44-7669	LUAD	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.5641
p.P567S	DO25262	LUAD	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.5641
p.A561V	TCGA-AA-A01P	COAD	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.25
p.A561V	DO8642	COAD	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.25
p.A565T	TCGA-B0-5098	KIRC	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.7139
p.A565T	DO18938	KIRC	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.7139
p.F576C	TCGA-DK-A6AW	BLCA	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.7108
p.F576C	DO48566	BLCA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.7108
p.P584S	TCGA-EE-A2MU	SKCM	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.1111
p.P584S	DO37436	SKCM	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.1111
p.R556K	TCGA-FR-A726	SKCM	TCGA	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.1111
p.R556K	DO48665	SKCM	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.1111
p.Q570K	DO229015	LICA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.5833
p.D571E	DO229045	LICA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.5647
p.Y572H	DO229057	LICA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.6118
p.Y572H	SIDM00296	Small Cell Lung Carcinoma	GDSC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.6118
p.Y572H	ACH-002051	Lung Cancer	CCLE	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.6118
p.Y572H	LU-134-A	lung	COSMIC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.6118
p.P566L	DO231018	LUSC	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.7582
p.M574I	DO222868	MELA	ICGC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.6507
p.D585N	SIDM01175	Other Sarcomas	GDSC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.0833
p.D585N	SW684	soft_tissue	COSMIC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.0833
p.Q581K	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.1944
p.Q581K	NCI-H2023	lung	COSMIC	LAPPWEQDYRMMF	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RT6	cTAGE family member 2	DEG_ODPH_VHL_1	564:576	LAPPWEQDYRMMF	VHL	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPWEQDYRMMF

Degron related mutations and impact score

Drug responses associated with CTAGE1 mutations

All proteins holding degron of LAPPWEQDYRMMF