DegronMD - P40145(ADCY8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1142Y	TCGA-05-4398	LUAD	TCGA	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.1667
p.S1159G	TCGA-18-3417	LUSC	TCGA	DYR	CBL_MET	1148:1150	Mutation blocking phosphorylation signal	0.5278
p.P96L	TCGA-55-8507	LUAD	TCGA	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.7582
p.P96L	DO233884	GACA	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.7582
p.P96L	DO233804	GACA	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.7582
p.P96L	DO45412	LUAD	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.7582
p.A1146T	TCGA-75-5126	LUAD	TCGA	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.2778
p.A100V	TCGA-A6-2686	COAD	TCGA	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.2222
p.A100V	DO7828	COAD	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.2222
p.A100V	DO233156	GACA	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.2222
p.R99L	TCGA-CV-7424	HNSC	TCGA	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.25
p.R99L	DO14998	HNSC	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.25
p.R1150P	TCGA-CV-A6JM	HNSC	TCGA	DYR	CBL_MET	1148:1150	Mutation altering degron motif	0.7512
p.G1157S	TCGA-WE-A8ZX	SKCM	TCGA	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.1389
p.G105S	DO10841	ESAD	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.0833
p.G105S	DO234466	ESAD	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.0833
p.T103I	DO233712	GACA	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.1389
p.G105A	DO230942	LUSC	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.0833
p.G105A	DO224589	LUSC	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.0833
p.G95C	DO26769	LUSC	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.6489
p.P90A	DO220843	MELA	ICGC	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.6392
p.L1138P	SIDM01277	Esophageal Carcinoma	GDSC	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.0556
p.G1144S	SIDM01175	Other Sarcomas	GDSC	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.2222
p.G1144S	ACH-002309	Sarcoma	CCLE	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.2222
p.G1144S	SW684	soft tissue	COSMIC	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.2222
p.D1142G	SIDM00193	Colorectal Carcinoma	GDSC	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.1667
p.D1142G	ACH-000991	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.1667
p.D1142G	SNU-81	large intestine	COSMIC	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.1667
p.L83V	SIDM00710	Small Cell Lung Carcinoma	GDSC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.25
p.L83V	ACH-000394	Lung Cancer	CCLE	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.25
p.I1139N	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.0833
p.I1139N	ACH-002311	Esophageal Cancer	CCLE	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.0833
p.I1139N	TE-12	oesophagus	COSMIC	DYR	CBL_MET	1148:1150	Mutation rewiring degron network	0.0833
p.R99Q	SIDM01098	Neuroblastoma	GDSC	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.25
p.R99Q	ACH-001188	Neuroblastoma	CCLE	DSALPLYSLGP	CBL_PTK	86:96	Mutation rewiring degron network	0.25
p.D86N	ACH-000975	Lung Cancer	CCLE	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.5821
p.S93L	ACH-001664	Gastric Cancer	CCLE	DSALPLYSLGP	CBL_PTK	86:96	Mutation altering degron motif	0.7667

Kaplan plot for ADCY8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADCY8

UniProt ID: P40145

Entrez ID: 114

Protein name: Adenylate cyclase type 8 (EC 4.6.1.1) (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (AC8) (Ca(2+)/calmodulin-activated adenylyl cyclase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADCY8 in