DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSALPLYSLGP
Uniprot ID:
P40145
Source protein:
Adenylate cyclase type 8
Source gene:
ADCY8
Class:
CBL_PTK
Location:
86:96
E3 ligase:
CBL
DEGRON score:
0.9774
ASA_SCORE:
75.9182
COIL:
0.8776
CONS_SCORE:
0.3341
DSS_SCORE:
0.5911
HELIX:
0.0874
FCONS_SCORE:
0.8954
RIG_SCORE:
0.6636
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P96L
TCGA-55-8507
LUAD
TCGA
DSALPLYSLGP
CBL_PTK
0.7582
p.P96L
DO233884
GACA
ICGC
DSALPLYSLGP
CBL_PTK
0.7582
p.P96L
DO233804
GACA
ICGC
DSALPLYSLGP
CBL_PTK
0.7582
p.P96L
DO45412
LUAD
ICGC
DSALPLYSLGP
CBL_PTK
0.7582
p.A100V
TCGA-A6-2686
COAD
TCGA
DSALPLYSLGP
CBL_PTK
0.2222
p.A100V
DO7828
COAD
ICGC
DSALPLYSLGP
CBL_PTK
0.2222
p.A100V
DO233156
GACA
ICGC
DSALPLYSLGP
CBL_PTK
0.2222
p.R99L
TCGA-CV-7424
HNSC
TCGA
DSALPLYSLGP
CBL_PTK
0.25
p.R99L
DO14998
HNSC
ICGC
DSALPLYSLGP
CBL_PTK
0.25
p.G105S
DO10841
ESAD
ICGC
DSALPLYSLGP
CBL_PTK
0.0833
p.G105S
DO234466
ESAD
ICGC
DSALPLYSLGP
CBL_PTK
0.0833
p.T103I
DO233712
GACA
ICGC
DSALPLYSLGP
CBL_PTK
0.1389
p.G105A
DO230942
LUSC
ICGC
DSALPLYSLGP
CBL_PTK
0.0833
p.G105A
DO224589
LUSC
ICGC
DSALPLYSLGP
CBL_PTK
0.0833
p.G95C
DO26769
LUSC
ICGC
DSALPLYSLGP
CBL_PTK
0.6489
p.P90A
DO220843
MELA
ICGC
DSALPLYSLGP
CBL_PTK
0.6392
p.L83V
SIDM00710
Small Cell Lung Carcinoma
GDSC
DSALPLYSLGP
CBL_PTK
0.25
p.L83V
ACH-000394
Lung Cancer
CCLE
DSALPLYSLGP
CBL_PTK
0.25
p.R99Q
SIDM01098
Neuroblastoma
GDSC
DSALPLYSLGP
CBL_PTK
0.25
p.R99Q
ACH-001188
Neuroblastoma
CCLE
DSALPLYSLGP
CBL_PTK
0.25
p.D86N
ACH-000975
Lung Cancer
CCLE
DSALPLYSLGP
CBL_PTK
0.5821
p.S93L
ACH-001664
Gastric Cancer
CCLE
DSALPLYSLGP
CBL_PTK
0.7667
Drug responses associated with ADCY8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSALPLYSLGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P40145
Adenylate cyclase type 8
CBL_PTK
86:96
DSALPLYSLGP
CBL
0.9774
More...