DegronMD - Q2TAA8(TSNAXIP1)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R31L	TCGA-44-2662	LUAD	TCGA	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.2778
p.E581Q	TCGA-D8-A1JA	BRCA	TCGA	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.E582K	TCGA-EE-A2MR	SKCM	TCGA	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1667
p.R29W	TCGA-EO-A22R	UCEC	TCGA	DYR	CBL_MET	27:29	Mutation altering degron motif	0.8634
p.R31Q	TCGA-FS-A1ZQ	SKCM	TCGA	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.2778
p.Q38H	DO8264	COAD	ICGC	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.0833
p.W579R	DO234149	ESAD	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0833
p.R592H	DO233191	GACA	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8244
p.R592H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8244
p.R592H	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8244
p.G578S	DO14750	HNSC	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S603I	DO229037	LICA	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.M578T	DO229253	THCA	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.S36R	DO234133	THCA	ICGC	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.1389
p.P19S	DO42673	UCEC	ICGC	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.1111
p.D26N	ACH-000964	Leukemia	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.3056
p.P23S	ACH-000991	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.2222
p.P23S	SNU-81	large intestine	COSMIC	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.2222
p.K22E	ACH-000997	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	27:29	Mutation substituting flanking lysine	0.3056
p.K22E	ACH-001061	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	27:29	Mutation substituting flanking lysine	0.3056
p.K22E	HCT-15	large intestine	COSMIC	DYR	CBL_MET	27:29	Mutation substituting flanking lysine	0.3056
p.Y28H	ACH-002134	Lung Cancer	CCLE	DYR	CBL_MET	27:29	Mutation altering degron motif	0.7229
p.Y28H	H2818	pleura	COSMIC	DYR	CBL_MET	27:29	Mutation altering degron motif	0.7229
p.H38R	ACH-002462	Non-Cancerous	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.0833
p.H38R	ACH-002463	Non-Cancerous	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.0833
p.H38R	ACH-002464	Non-Cancerous	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.0833
p.H38R	ACH-002465	Non-Cancerous	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.0833
p.H38R	ACH-002466	Non-Cancerous	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.0833
p.H38R	ACH-002467	Non-Cancerous	CCLE	DYR	CBL_MET	27:29	Mutation rewiring degron network	0.0833
p.E581D	KO52	haematopoietic and lymphoid tissue	COSMIC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.E581D	LNCaP-Clone-FGC	prostate	COSMIC	LRGGLMTID	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSNAXIP1

UniProt ID: Q2TAA8

Entrez ID: 55815

Protein name: Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSNAXIP1 in